propecia cancerogeno food and drug

[surferste]

Kevin

unregistered user

03-18-03, 12:51 PM (EST)

 

"Be careful, Propecia proved to be cancerous !!!!"

 

http://www.youngagain.com/proscar.html

Such an irony!, the so-called anti-cancerous drug has proven to cause cancer. The FDA worth #####!.

[Aragorn]

Non ho il tempo di tradurla ora, ma è davvero preoccupante.

Careca, ci daresti un tuo parere?

 

Ronald K. Ross, professor of preventive medicine and deputy director of the USC/Norris Cancer Center.

 

Finasteride Found to Be a cause of Prostate Cancers, USC study finds

by Eva Emerson, University of Southern California

 

A new study by USC/Norris Cancer Center scientists raises serious questions about the potential use of the drug finasteride to prevent prostate cancer.

 

Scientists had theorized that finasteride, sold under the brand name Proscar and commonly used to treat benign prostate disease, might offer men a way to cut their risk of developing prostate cancer.

 

Yet, "it appears that finasteride may not be effective as a chemopreventive agent against prostate cancer, at least in men with high PSA levels," said Ronald K. Ross, professor of preventive medicine and deputy director of the USC/Norris Cancer Center.

 

"There may even be a subgroup of patients in whom the drug actually could be harmful," said Richard Cote, associate professor of pathology and urology. Ross, Cote, and Eila C. Skinner, associate professor of urology, led the study, which appears in the August issue of the British Journal of Cancer.

 

Prostate cancer is the most frequently diagnosed cancer in the United States, and proves fatal for some 40,000 men each year. At present, there's no proven way to prevent the disease.

 

USC/Norris researchers have long led research on the role of the male hormones (androgens) in spurring prostate cancer growth. Ross and his colleagues first proposed that lowering levels of the androgen most active in the prostate, called dihydrotestosterone (DHT), could possibly prevent prostate cancer.

 

Ross' team was also the first to suggest that finasteride, which lowers the levels of DHT by blocking the enzyme that converts testosterone into DHT, might prevent the formation of prostate cancer.

 

The National Cancer Institute (NCI) is in the midst of a large national clinical trial to determine if finasteride can reduce the incidence of prostate cancer. The seven-year NCI study has enrolled more than 18,000 healthy men with normal PSA levels.

 

Right now, finasteride, manufactured by Merck & Co., is used most commonly to shrink the enlarged prostate glands of men with benign prostate hyperplasia and thereby improve symptoms. A lower dose of finasteride was approved by the FDA last year to treat cosmetic, incipient hair loss and is marketed under the brand name Propecia. Although small, the new USC/Norris study seems especially significant in light of this ongoing trial, researchers say. "Ours are the first data to address the question of whether finasteride prevents disease. The results are not reassuring," Ross said.

 

In contrast to the NCI study (which is focusing on healthy men), the USC team studied 52 men with elevated blood levels of PSA (prostate specific antigen) whose biopsies showed no signs of prostate cancer. PSA is a protein produced only by prostate cells that doctors use as a broad, though fallible, screen for prostate cancer. Because all of the men in this study had elevated PSA levels, they were considered to have a higher risk of developing prostate cancer than men with normal PSA levels.

 

Half of the men were treated with finasteride for one year, while the other half received no treatment.

 

At the end of the study, a second biopsy revealed that eight of the 27 men who took the drug had developed tumors, compared to only one of the 25 men in the observation-only group.

 

To evaluate the drug's ability to block tumor development, Cote, Ross and Skinner tracked key intermediate markers of disease, a novel approach to testing new chemopreventive agents. They measured the participants' blood levels of testosterone, PSA and dihydrotestosterone; they also compared tissue samples from the biopsies at the start of the study to those at the end.

 

While men in the control group showed no changes in blood levels of PSA, testosterone or dihydro-testosterone, the treated men's PSA levels dropped by 48 percent and dihydrotest-osterone levels fell by 67 percent . However, men in the treatment group saw their testosterone levels rise by 21 percent during the study.

 

The team also looked at tissue samples for a marker of benign disease - called hyperplastic epithelial tissue - and two markers associated with increased risk of prostate cancer - the presence of precancerous lesions known as PIN (prostate intraepithelial neoplasia) and the rate of cell proliferation in the prostate gland. They found that, as expected, finasteride reduced the proportion of the hyperplastic epithelial tissue. But, the drug had no effect on PIN or proliferation, which are more strongly linked to the development of cancer.

 

The results suggest that though finasteride lowers DHT levels, the net effect of hormones acting on the prostate may be unchanged by the drug, according to Ross. That may be because of rising testosterone levels in the men taking finasteride. Although not as potent as DHT, testosterone can also spur prostate cell growth. "The biology is not as straightforward as many people have assumed," Ross concludes.

 

Notably, of the eight men who had precancerous PIN lesions at the start of the study and treated with finasteride, six developed cancer after one year. In comparison, in the no-treatment group, none of the five men with precancerous PIN lesions got cancer. This finding, though in a small sub-group of the men, was statistically significant, leading researchers to write, "finasteride is unlikely to be useful and may even be harmful in men with PIN."

 

"If finasteride were to have had an anti-cancer effect, it is likely that it would have showed up in these patients," Ross said. The USC team holds off, however, on predicting the results of the national trial.

 

"It is possible that the drug could have a beneficial effect in preventing prostate cancer in some men, though the results of this study suggest that this is unlikely," he said.

 

Richard J. Cote, Eila C. Skinner, Carol E. Salem, Susan J. Mertes, Frank Z. Stanczyk, Brian E. Henderson, Malcolm C. Pike, and Ronald K. Ross. "The effect of finasteride on the prostate gland in men with elevated serum prostate specific antigen (PSA) levels." British Journal of Cancer, vol. 78, No. 3, August 1998.

 

HSC Public Relations page HSC Weekly index Last modified August 12, 1998

[Aragorn]

Ho trovato uno studio che afferma il contrario.

Ma si può andare avanti così.

Ma dove l'hanno presa la laurea questi ricercatori, al processo di Biscardi?

 

J Urol 2002 Nov;168(5):1985-8 Related Articles, Links

 

Effect of nonsteroidal anti-inflammatory agents and finasteride on prostate cancer risk.

 

Irani J, Ravery V, Pariente JL, Chartier-Kastler E, Lechevallier E, Soulie M, Chautard D, Coloby P, Fontaine E, Bladou F, Desgrandchamps F, Haillot O.

 

University Hospital of Poitiers, France.

 

PURPOSE: We examine the relationship of nonsteroidal anti-inflammatory drugs and finasteride on the risk of prostate cancer. MATERIALS AND METHODS: Participants in this case control study using a prospective collection of data were drawn from consecutive patients who underwent prostate biopsy at 12 different departments of urology from January 1999 to June 2000. Medication use was assessed by self-questionnaire as well as questions about dietary and lifestyle factors that might be relevant for prostate cancer risk. RESULTS: The study included 639 patients with prostate cancer and 659 cancer-free controls. Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99). After adjusting for potential confounders, the protective effect of nonaspirin nonsteroidal anti-inflammatory drugs was no longer significant (OR, 0.84, 95% CI 0.66-1.07), while finasteride showed a significant protective effect (OR 0.58, 95% CI 0.37-0.92). CONCLUSIONS: The results suggest that finasteride could have a chemopreventive role in prostate cancer. While aspirin did not show any impact on prostate cancer risk, the role of nonaspirin nonsteroidal anti-inflammatory drugs warrants further studies.

[CAPEJUS]

Mmmma!

Cmq..che possa provocare il cancro alla prostata una molecola nata x curare l'ipertrofia prostatica..è alquanto strano..non da escludere..ma lo scoprono ora..dopo 20 anni di sperimentazione..!

Dopo..che non faccai bene bene..non lo metto in dubbio..come ogni medicina..ha i suoi pro ed i suoi contro..!

Ciaoooooo!

[BoyRM76]

Andate su www.altavista.it, cercate vicino a STRUMENTI il link che dice "traduzione", là potete mettere l'indirizzo della pagina web inglese che volete tradurre...non sarà il massimo ma almeno è un po' più comprensibile anche a chi non conosce l'inglese.

[macom]

A quanto sembra lo studio è stato fatto nel 1998 mi sbaglio??? E quindi 5 anni sono passati in silenzio!

Pertanto le ipotesi sono due:

1-O ci tengono nascosto questo terribile effetto collaterale

2-E' una di quelle notizie senza fondamento o comunque che non è stata successivamente provata oppure smentita

 

Speriamo bene, incrociamo le dita e grattiamoci i c......i o perlomeno quello che c'è rimasto!

[Purga man]

cazzarola .. se prima avevo un motivo di non usare fina ...ora ce ne ho 2... azzarola ! ciauz

[simo81]

DOOOOOOHH!!!!!!! No ragà questa nn ci voleva proprio, ora che ho iniziato ad usarla! anke se nn fosse vera ora mi ci fate venì il dubbio! io già ho paura dell'impotenza e voi mi caricate la briscola???!!! nooooooooooo!!!!!!!!!!!!!

[Cuper]

Si ma sveglia raga!!!!!

Si parla di Proscar per intero cioè 5 mg di principio attivo non di 1 mg usato per i nostri scopi.

Se usassimo i 5 mg ci accorgeremo subito che gli effetti collaterali impedirebbero di continuare ad assumerla no????

Speriamo cmq in un intervento dell Dott. Careca

Con affetto Cuper.

[Aragorn]

Comunque ho letto meglio entrambi gli studi, anche se devo dire che xxx mi aveva fatto prendere un bello spavento.

Il primo studio quello che dice che finasteride induce il tumore prostatico è stato eseguito su un numero troppo basso di soggetti 27 per finasteride e 25 per placebo. Nel primo gruppo 7 soggetti hanno sviluppato una neoplasia contro 1 solo del secondo gruppo. Sono numeri troppo bassi per essere scientificamente significativi.

Il secondo studio comprende una numerosità maggiore 639 e 659, quindi già i numeri sono più significativi.

Ci dovrebbero comunque essere entro il 2003 gli esiti di uno studio su 18000 soggetti, che dovrebbe essere più esaustivo.

[giorgio73]

Conosco molto bene l'inglese, e mi sono letto con molta attenzione l'articolo.

 

Vi faccio presente che il gruppo dei 52 individui su cui è stata fatta la ricerca era un gruppo di persone con alti valori del PSA. Avere alti valori del PSA significa essere ad alto rischio di sviluppare, o forse aver già sviluppato, un tumore prostatico. In più, le stesse persone presentavano delle lesioni pre-cancerose sul tessuto prostatico.

Si tratta in sostanza di un gruppo di studio molto "particolare": in linea di massima tutte quelle persone erano altamente predisposte a sviluppare un tumore prostatico.

 

Non mi pare che da uno studio del genere sia corretto aprire un post con il titolo: "Finasteride cancerogena..."

Sono solo messaggi allarmistici, tenuto conto che esiste uno studio, a più ampio raggio e rivolto a persone con valori di PSA normale (come immagino e spero siamo tutti noi di questa community) che parrebbe dimostrare un certo effetto protettivo della finasteride nei confronti del rischio di sviluppare un tumore alla prostata.

 

Ma voi l'avete mai seguita la storia della pillola contraccettiva femminile? Ad oggi c'è qualcuno che continua a sostenere che aumenterebbe il rischio di tumore al seno. In realtà, complessivamente la pillola contraccettiva ha piuttosto un effetto preventivo verso le forme tumorali al collo dell'utero: questa è scienza.

Che poi abbia altri effetti collaterali, avvertiti in modo più o meno soggettivo (una certa ritenzione idrica, ad esempio) è anch'esso un dato di fatto.

Ma da qui a parlare di rischio tumorale, ce ne vuole!

 

Suvvia, cerchiamo di essere persone intelligenti e moderate, e di non alimentare allarmismi infondati che non giovano a nessuno!