Hm: Pronta Per Il 2007

[Ho Chi Minh]

Ho letto giusto oggi vari interventi, senza capo ne coda, di gente che si insultava sulla reale possibilita' di avere a breve la HM...

 

Pubblico qui l'intervista fatta nel Dicembre 2002 al Dr. Ken Washenik, il Direttore dell'istituto di Ricerca Aderans (Stati Uniti) uno dei 4 o 5 gruppi di ricerca nel mondo che stanno SERIAMENTE lavorando all'HM con scopo commerciale (cioe' renderla nel breve disponibile a prezzi paragonabili a quelli dei trapianti attuali).

 

Delle parole di questo dottore mi fido molto di piu' delle chiacchiere di perditempo del forum che parlano solo perche' hanno la bocca (anzi, scrivono solo perche' hanno le dita) senza avere nessuna informazione in proposito.

 

Nessuno sa se la HM sara' veramente realta' in futuro.

Io, da quello che ho letto e dalle informazioni che ho trovato, sono positivo e ci conto sinceramente. :supersorriso: :supersorriso: :supersorriso:

 

Nota:

ho selezionato solo le domande che ritenevo piu' interessanti per questo forum.

Chi volesse leggere l'intervista completa (10 pagine web!!!) puo' armarsi di pazienza, di un buon vocabolario e cliccare su

 

http://www.hairlosshelp.com/hair_cloning/c...ew_washenik.cfm

 

Buona speranza a tutti

lo zio

[Ho Chi Minh]

HairlossHelp.com conducted this revealing two hour interview with Dr. Ken Washenik at the Aderans Research Institute's offices in Beverly Hills, California in December 2002.

 

HAIRLOSSHELP: How successful was that research?

DR WASHENIK: If you look at publicly presented publications on this technology, hair cloning, there are only two records of people having done that with human hair. One was Colin Jahoda who had that paper published in Nature, and the other one was Tom Barrows from Bioamide who presented a paper at a bio engineering conference in Switzerland in 2001. Bioamide did grow hair in one patient using cultured dermal follicular fibroblasts or dermal papilla cells. So they are the only ones who have taken human cells, cultured them, injected them back into a person and have gotten hair to grow.

 

HAIRLOSSHELP: Was this follicular neogenesis, creating brand new follicles from scratch, or reactivating an existing dormant follicle?

DR WASHENIK: It was follicular neogenesis, creating a follicle from scratch. Now not enough work has been done yet for us to know if this will always be the case. We don’t know if a surgeon who places a progenitor of cells near a dormant follicle will cause it to be reactivated. I would prefer that this be the case because then we don’t have to worry about direction, location and naturalness of the hair. So that’s my fantasy but it looks for now like it will be follicular neogenesis.

 

HAIRLOSSHELP: When was this procedure done and was it performed on one of their staff members?

DR WASHENIK: No this was a patient and it was done just over a year ago.

 

HAIRLOSSHELP: Some people have diffuse loss and some have pattern loss, who are the best candidates for this follicular neogenesis or hair cloning technology?

DR WASHENIK: Early on, the way this has been looked at is a system that’s called autologous where you take cells from one person, culture them, and put them back into the same person. In that case it probably won’t have any use for patients with alopecia areata, alopecia universalis and alopecia totalis because that’s an immune system disease and not a disease of the hair. But for people with scars or androgenetic alopecia or people with congenital lack of hair, burn victims; people who just have areas where they cant grow hair, it should work fine for all those. In fact it would even work for people who don’t even have a medical condition and just want more dense and thicker hair.

The dilemma however, with diffuse loss is that you may select cells from the back of the head that may still be subject to thinning. However it’s not necessarily that bad because you may just be able to buy them some additional years of hair even if it’s not permanent. Its often 20 years before you go bald from puberty, so these people may still he able to benefit for a long time.

 

HAIRLOSSHELP: Would they be able to have a second treatment after that if they do lose that hair?

DR WASHENIK: Absolutely, they could still conceivably come back in say another 2 years and get another 10,000 hair seeds implanted.

 

HAIRLOSSHELP: In the future when this is being done, how long would it take from the time the hair seeds or hair progenitors are implanted, to the time they start to see hair growing?

DR WASHENIK: Probably right around 3 months.

 

HAIRLOSSHELP: When this technique comes out will you still be doing conventional transplants and will there still be a need to do conventional transplants?

DR WASHENIK: I think when the first generation comes out some people who lack a good hairline may need a conventional transplant just in the front, and then during the procedure their cells will be harvested and they will return 3-4 weeks later to get added density from the implanted hair cells. In others who already have good hairlines and just need increased density, they will just be able to have the hair cells cultured and implanted.

 

HAIRLOSSHELP: What about the next generation of this treatment? What will that offer and when will it become available?

DR WASHENIK: The next generation, which I think will come about 1-5 years later, will be able to make use of other peoples cells. So you would be able to get hair cells out of a bank, like a blood bank, and implant them into anyone. Then you will be able to pick and choose what type of hair and color you want. Although, some researchers seem to think that the person-to-person or allogeneic procedure, will come out sooner than the allopathic procedure. Their feeling is that its much more promising because in that case it’s consistent. When you have different patients you are dealing with there are different variables based on their individual characteristics. When you are working with the same follicular fibroblasts all the time, you cut down on the number of variables giving you a more consistent result.

 

HAIRLOSSHELP: Is there any limit to the density that can be achieved with follicular neogenesis?

DR WASHENIK: The limitations of how densely you can pack a scalp with a follicle based hair transplant are completely spatial. With cell based transplants you can pack them in as close as you can with regular transplants. But you can still come back later and do more of them to get even greater density. As long as spatially there is enough room to introduce an instrument to implant then, there are no limitations in terms of what density you can achieve.

 

HAIRLOSSHELP: How long would a person have to wait between each implantation session?

DR WASHENIK: I would guess about one or two weeks.

 

HAIRLOSSHELP: Will there be any issue with where the follicles will be implanted like the hairline? And will the hairs be bigger or smaller and what about the direction of growth and things of that nature?

DR WASHENIK: It should look the same. Now there are some issues that will still have to be fine-tuned and finessed before this thing is ready to go. We need to know if there are a certain critical number or mass of cells you need to implant to get a certain diameter of hair. If there is then we can use this number to control the thickness of hair shafts so we can make a more natural hairline. We could even duplicate things like follicular units by planting groupings of cells together. As far as direction of hair growth goes you would have to be able to control the direction of the hair growth. Now in the back it won’t make much difference, but in the front the angle of growth will be critical for a natural appearance. And that goes back to my previous comment where you may need to have hairs transplanted there to establish a natural looking hairline and the density will then be made up of the new follicles.

 

HAIRLOSSHELP: This big question that everyone obviously wants to know is how long will it take to develop this hair cloning or follicular neogenesis technique?

DR WASHENIK: I have been saying 5 years from the inception of Aderans Research Institute, which opened on July 1, 2002; but I want everyone to know that I am just guessing, it could be sooner.

 

HAIRLOSSHELP: Is that 5 years to commercial release?

DR WASHENIK: I think it’s realistic that 5 years from the opening of ARI we will have a commercially available product or a technology that’s in the latter stages of development. Now bear in mind that research takes its own course so things may change. But let me explain why I say 5 years. If you take something like a brand new technology, it would likely take 3 years to get through the regulatory process. That’s why I think it’s reasonable, because I’m being conservative. Right now no researcher knows the exact regulatory steps the FDA will place on this procedure because it is brand new. There are not a lot of bioengineered organs you can point to to know exactly what the FDA will require. So I think 3 years is a reasonable period for regulatory pathway trials. That then means I am giving 2 years to get the actual package of technology together for submission to the FDA or appropriate regulatory authority so we can go forward with the clinical trials

 

HAIRLOSSHELP: The last question I have is what do you envision the cost being for people to get this procedure done?

DR WASHENIK: That’s a question like the time issue, its completely unknown. Yet I would venture to say somewhere around the cost of a traditional transplant. It all depends on how much it will cost from a laboratory standpoint. I would hope that it will be in the same ballpark but right now I just don’t now. If I had to guess I would say somewhere between $7,000-$15,000.

[troppicapelli]

Credo che l'unica speranza che bisognerebbe avere sia solo quella legata ai tempi di realizzazione-diffusione : per il resto non è nemmeno questione di fiducia o di ottimismo. Tutte le ricerche che vengono costantemente menzionate (hm, clonazione ecc.) sono una realtà : nessun investitore, centro di ricerca, azienda, medico è disposto a perdere tempo e denaro se una cosa non funziona. Il fatto stesso che da più parti del mondo se ne parla, che case farmaceutiche si fondono, che luminari si scambiano conoscenze, che nuovi laboratori nascono, in questa precisa branca di ricerca, vuol dire semplicemente che qualcosa di valido è stato trovato. Credo sia la nuova corsa all'oro: è un settore, per il primo che arriva con una soluzione seria, che può creare una ricchezza mostruosa. Ecco perchè tutti ci lavorano; ed ecco perchè, se una ricerca è promettente, tutti si mettono a percorrere la strada aperta. L' hm è una realta scientifica già sperimentata. Non possono, fino a quando non avranno tutta la situazione in mano, divulgarla ed offrirla al pubblico. Senza contare la naturale reticenza dei ricercatori (paura di fare brutta figura, spionaggio industriale, sicurezza personale ecc.) che invita alla solita cautela che sembra pessimismo. Ma la verità è che, almeno per l' hm, avremo presto importanti notizie : personalmente confido molto nel dott. Gho e nel mese di Settembre quando sicuramente ci darà la notizia che tutti aspettiamo. E chi se ne frega se il costo sarà alto : con tutti i soldi che uno butta in lozioni, trattamenti, cosmetici, trapianti e copertoni sulla testa, spendere qualche milione (in lire) per riavere i propri capelli in testa non credo sia unrande sacrificio per nessuno. Non fosse altro per terminare il lungo calvario...

[cripto]

personalmente confido molto nel dott. Gho e nel mese di Settembre quando sicuramente ci darà la notizia che tutti aspettiamo

da quello che so io, a settembre le uniche notizie da attendere sono quelle dal messico (bazan). gho, che io sappia, non ha particolari scandenze a breve. Tutte le volte va ai convegni, tutte le volte parla molto della sua FUE e poco della HM.

Attualmente, le ultime indiscrezioni su gho alle quali dare peso secondo me, sarebbero quelle che parlano dei sue protocolli di sperimentazione. E più precisamente del fatto che ha 3 protocolli principali di ricerca, e che non ce n'è uno che va bene per tutti, ma almeno uno dei tre da buoni risultati di consistenza in ogni paziente. Il lavoro che "starebbe" facendo ora, sarebbe quello di tentare di trovare un unico protocollo, efficace per tutti, da presentare alle varie organizzazioni che devono approvare la procedura. Nel caso americano, ad esempio, è la FDA.

[curvadong]

Grazie cripto.