Renato

Sbaglio o questi qui vendono il RU58841? E' nella lista prodotti... qualcuno che parla o scrive benissimo l'inglese (Salus, Tigrotto, Hairgod...) che telefona o scrive e si informa? http://www.faitheaglepharm.com/prod6.html

Pero' a me pare di aver capito che esce prima in Europa per la prostata...

Direttamente da alt.baldspot... GlaxoSmithKline submits European Marketing Authorisation Application for dutasteride to treat BPH London, October 4, 2001 - GlaxoSmithKline plc (GSK) today announces that it has submitted a European Marketing Authorisation Application (MAA) for dutasteride, a new treatment for Benign Prostatic Hyperplasia (BPH), to the Swedish Regulatory Authorities (MPA). Clinical trials for dutasteride, involving over 4,300 patients suffering from BPH, have demonstrated that it provides long lasting symptom relief and positively impacts on disease progression. Dutasteride is the first 5-alpha reductase enzyme inhibitor (5ARI) that inhibits both types 1 and 2 isoenzymes. These enzymes are responsible for converting testosterone to dihydrotestosterone (DHT) in the prostate, which are proven to play a key role in the development and progression of BPH. BPH is a common benign growth in man and pathological changes of this disorder can be found in approximately 50% of men in their 50s and up to 90% of men in their 90s1. BPH is defined as a non-cancerous enlargement of the prostate gland, which can lead to the manifestation of lower urinary tract symptoms (LUTS). GlaxoSmithKline - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better and live longer. For company information, visit GSK on the World Wide Web at http://www.gsk.com Notes to the Editors: Untreated BPH of long duration can give rise to a reduction in quality of life2 and complications such as acute urinary retention (AUR) requiring hospitalisation, urinary tract infections, gross haematuria, bladder stones and rarely, renal failure. AUR is often considered by patients to be the most serious outcome of BPH and many symptomatic men are electing medical therapy in the hope of avoiding surgery. The NDA for dutasteride was filed with the FDA in December 2000, using 1 year data, and the sNDA (full 2 year data) will be filed once approval for the NDA is obtained. Current world-wide sales of treatments for BPH are £1,562 million, and in Europe are £574 million where annual growth is at a rate of +16%. Several factors are expected to contribute to the expansion of this market including an ageing population and increased awareness/screening. References: 1 Berry SJ, Coffey DS, Walsh PC, and Ewing LL: The development of human benign prostatic ayperplasia with age. J Urol, 1984;132:474-479 2 Natural History of prostatism: impact of urinary symptoms on quality of life in 2115 randomly selected community men. Girman C, Eptstein R, Jacobsen S, Guess H, Panser l, Osterling J, Lieber. Urology 44 (6): 825-831, 1994

Scusate se non sto seguendo ultimamente, ma cos'e' sta cura miracolosa del dr GHO che sta per uscire?

Hairlosshelp su alt.baldspot ha riportato un link al quale e' possibile visualizzare, diciamo cosi', quelli che sono i piani della Glaxo (la ditta che ha in produzione dutasteride)per il futuro prossimo. Ora: il file da scaricare e' in formato pdf ed e' consistentissimo: ergo io mi sono guardato bene dal farlo. Al thread iniziato da hairlosshelp e' pero' iniziata una discussione, nella quale e' emersa che dutasteride per la prostata sara' sicuramente disponibile nel 2002... Prendetela cosi' anche stavolta! http://corp.gsk.com/financial/jdc_merrill_...nch_25sep01.htm

Tempo fa ho letto che e' vero che Folligen contiene piu' tipi di copper peptides rispetto a Tricomin, ma e' altresi' vero che gran parte dei copter contenuti in Folligen non hanno niente a che fare con la cura dei capelli. Mentre Tricomin contiene soltanto rame peptidi specifici per la cura del cuoio capelluto. Per cui alla fine quale sara' meglio? Qualcuno che e' in contatto con Pickard ed ha voglia di chiederlo direttamente a lui?

Il miglior integratore per capelli secondo me e' PROGUARD. Proxi lo usa, fatevi dire cosa contiene.

Scusate se lo studio e' un'altra volta in inglese,ma salus e' in ferie, e quindi non glielo posso mandare affinche' lo faccia tradurre. Potevo aspettare? No! Leggete! E' un messaggio trovato su alt.baldspot :P Im now on propecia! and my hair is shedding now again! after using 1.5 years Propecia! But there is this drugs ..helping 8 of 10 men with his hairloss! Called Loniten ( 80% Responded with Hair Growth) But there is more side-effects!! ------------------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------------- We have received numerous requests for more info about Loniten (pronounced Lon-ah-tin) since we published the article on "Potent Drug Cocktail" for hair loss. We have done more research on Loniten and this is from Pharmacia & Upjohn - "80% of the patients reported hair growth". Loniten or oral minoxidil is actually intended for patients with high blood pressure. However, Loniten as an anti-hypertension drug has not been as successful as one may hope for Upjohn. Incidentally, a very commonly reported side effects of Loniten, namely hair growth, caught the attention of Upjohn. Rogaine or topical minoxidil is a spinoff from Loniten and turned out to be a multi-million dollar success for Upjohn as a hair loss treatment. Just as Rogaine is running out of steam as the best selling hair loss treatment is the world, people are turning their attention to low dosage oral minoxidil as a hair growth stimulant. According to Upjohn, "8 out of 10 patients reported hair growth" - This is a very significant statistics considering that this statement is from one of the world's largest and most highly respected pharmaceutical companies in the world. We have every reason to believe that the 80% claim is derived from numerous double-blinded independent testings on a very large group of test subjects, unlike some small clinics that produce similar claims based on privately conducted testings on a small group. Good news for women too. Pharmacia & Upjohn indicated that hair growth has been reported by women subjects as well. Upjohn listed "undesirable hair growth" as one of the side effects associated with Loniten. Specifically, 8 out of every 10 patients reported that body hair grew longer and darker while on Loniten. The hair growth usually starts within 3 - 6 weeks after beginning treatment. It is commonly reported that the hair growth tends to start on the forehead, temples, cheeks, and between the eyebrows. Subsequently, hair growth may be noticed on arms, legs and scalp. Some of HairSite readers also reported denser eyebrows and hair on the back while on treatment. Upjohn further added that the hair growth is not permanent. It will stop within 1 - 6 months after discontinuing the treatment. We have also confirmed the theory that Loniten has to be taken with a diuretic such as Spironolactone. Publications from Upjohn explicitly stated that a diuretic "must be" taken in conjunction with Loniten in most cases. The rationale is that while Loniten lowers blood pressure, your body's defense mechanism will automatically return your blood pressure to the original elevated level. Your body accomplishes that by retaining water and salt so that there will be more fluid to pump throughout the body. So in order for Loniten to be safe to consume, it is necessary to use a diuretic medication to remove excess water and salt from your body. Spironolactone is a natural choice for most hair loss sufferers since not only is Spironolactone a diuretic, it is also a potent anti-androgen. Loniten comes with many undesirable side effects and it is important that you consult your doctor before using this medication. Among some of the side effects are: 1) Salt and water retention - It is important to monitor your body weight closely while on Loniten. If Loniten is used without a diuretic, rapid weight gain by means of water and salt retention can happen within a few days, leading to increased plasma and interstitial fluid volume and local or generalized edema. Diuretic treatment alone or in conjunction with restricted salt intake will usually reduce the likelihood of water retention. You should consult your doctor immediately if you quickly gain weight of five or more pounds or if there is any swelling or puffiness in teh face, hands, ankles or stomach area. These are signs that you are retaining water. 2) Rapid heart rate - Loniten increases heart rate and it is not uncommon that your doctor would suggest taking another medication to reduce heart rate. To test if you have increased heart rate, you should count your pulse rate while you are resting. If you notice an increase of 20 beats or more over your normal pulse rate, contact your doctor immediately. 3) Interaction with Guanethidine - Administering Loniten to patients already taking Guanethidine can result in serious orthostatic effects. If possible, discontinue guanethidine well before using Loniten. 4) Other side effects include increased difficulty in breathing, new or aggravating pain the the chest, shoulder or arm, severe indigestion, dizziness, lightheadedness or fainting, breast tenderness, nausea and vomiting. Loniten comes in 2.5 mg , 5mg and 10 mg dosage.

E che si dice depeche? Un trafiletto, una pubblicita', o uno studio medico?

Ah caro Salus, ricorda come ando' l'altra volta quando decidesti di immolarti per la causa... Piuttosto non e' che ti conviene contattare qualche paziente in cura con il metodo Sitri e vedere come gli va?

Docale, ora ti faccio una domanda scema!! Dunque, io faccio un litro circa di the verde la mattina, e poi me lo bevo durante la giornata. Secondo te quando arriva a sera, perde i suoi effetti, oppure il fatto che non lo consumo subito non influisce sulle sue potenzialita' benefiche?

Lover, dov'e' che avevi letto che il the verde accresce gli effetti di fina?

Proxi a che serve questo kalo hair? A che serve?

Ciao Careca! Dunque, hai detto che per una questione di metabolismo dopo un po' si dovrebbe assumere una quantita' maggiore di fina. Secondo te dopo il terzo anno dovrei cominciare ad assumere magari 1,5 mg o 2? Tu che faresti per evitare l'assuefazione?

C'e' un cruccio che mi tormenta. Secondo voi chi usa gia' finasteride, con l'assunzione di duta, vedra' magari per qualsiasi motivo diminuire gli effetti positivi di quest'ultima? Non so, magari per una specie di assuefazione agli inibitori della 5 alfa?

Siamo in 3: ma non prendete lo studio in maniera cosi' assoluta xxxxx!

Irreversibility of hair follicle changes after 30 months of Androgenetic Alopecia. Konstantinova N, Korotkii N.G, Sharova N, Barhunova E, Gaevski D. Nioxin Research Inc, Atlanta, USA Moscow Medical University We studied horizontal and vertical biopsy from 15 Caucasian 24-41 year old males diagnosed with bitemporal recession Androgenetic Alopecia (AA) for 1.5 –18 years (average 7.4 years). All 15 biopsies were stained with H&E, Van Gsalus and with other collagen specific stainings. 1. Eleven pts with AA longer than 3 years had perifollicular fibrosis - collagen fibers were compact and formed a small scar-like formation around each anagen hair follicle(HF). Two patients - 33 year old with 18 month AA and 23 year old with 20 month AA did not have these hair follicle changes. Two 26-year-old patients with 30 and 36 month AA respectively were found to have some not so severe collagen fiber changes. 2. Infundibulum of HF dilatated 124-192 mm and most of them covered with keratinazed plug lacking normal hair shaft growth. 3. Decreased number of hair follicles 1.75-2,45 per sq. mm from 3.5-5 per sq. mm in control group. 4. None of anagen HF was situated in subcutaneous fat. We showed a correlation between length of the AA and severity/ thickness of perifollicular fibrosis. The result of this study is that any treatment of AA is recommended to start earlier than 30 months from first signs of AA. This should prevent irreversible collagen changes associated with “fibrotic incapsulation” of most anagen HF in involved areas, which usually leads to loss of normal blood supply, innervation, and subsequent miniaturization and prevention of hair from normal cycling.

See:http://www.hairlosstalk.com/tokyo62001.htm "Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle" : Toxicol Appl Pharmacol 2001 Feb 15;171(1):12-9 Related Articles, Books, LinkOut Critical role of calcium overloading in cadmium-induced apoptosis in mouse thymocytes. Shen HM, Dong SY, Ong CN. Centre for Environmental and Occupational Health, Department of Community, Occupational and Family Medicine, MD3, Faculty of Medicine, National University of Singapore, 16 Medical Drive, Singapore, 117597, Republic of Singapore. Cadmium (Cd) is a well-known environmental carcinogen and immunotoxin. Currently the direct cytotoxic effects of Cd on thymocytes are largely unexplored. The main objective of the present study was to investigate the apoptogenic property of Cd and the mechanisms involved, using primary cultured mouse thymocytes as a model. Cd-induced apoptosis in thymocytes was studied by TdT-mediated dUTP nick end-labeling assay and DNA gel electrophoresis. The results showed that Cd was able to cause apoptosis in mouse thymocytes in a time- and dose-dependent manner. Moreover, Cd exposure led to a rapid and sustained intracellular calcium (Ca2+) elevation, followed by caspase-3 activation and PARP cleavage, all of which preceded the characteristic DNA fragmentation. BAPTA-AM, a specific intracellular Ca2+ chelator, abolished Cd-induced Ca2+ overloading and subsequently inhibited caspase-3 activation, PARP cleavage, and apoptosis.It is believed that intracellular Ca2+ elevation may trigger caspase-3 activation either through mitochondria or through activation of Ca2+-dependent protease in Cd-treated thymocytes. Results from this study thus provide new information for a better understanding of the immunotoxic and immunomodulatory effects of Cd.

Ho cominciato appunto a mettere ALOE una volta a settimana. Non so se l'avevo detto, ma due volte a settimana uso anche il FABAO che avevo ordinato e che gia' sto usando da un paio d'anni. Io lo uso, pero' lo sconsiglio.

Liang, T.and Liao, S. 1997. Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase.J. Invest. Dermatol. 109(2):152. (BIO # 11242) The development and biological regulation of the male reproductive system is regulated by a group of steroid hormones called androgens, the most important being the sex hormones, testosterone, dihydrotestosterone (DHT) and androstenedione. Much of the testosterone that is produced is converted into the more active hormone, DHT. Androgens are involved in the development of several skin disorders including acne, seborrhea, common baldness and hirsutism. Several enzymes play important roles in the synthesis and activity of testosterone and DHT. A very important enzyme is 5-alpha reductase which is responsible for the conversion of testosterone to DHT. Therapeutic treatment of androgen-dependent diseases is often aimed at altering the levels and activity of 5-alpha reductase. Previous research by these investigators identified that certain unsaturated fatty acids, in particular GLA, inhibits 5-alpha reductase activity and hence the conversion of testosterone to DHT, in the liver and prostate of rats and humans. The objective of this study was to determine whether GLA could act as an inhibitor of 5-alpha reductase when applied topically. Hamster flank organ growth, as measured by the increase in the area of pigmented macule, is highly sensitive to androgen stimulation. This model is often used for testing androgenic and anti-androgenic compounds. The authors reported that topical treatment of one of the paired flank organs of a castrated hamster with testosterone caused an increase in size and darker pigmentation, results that were not present on the contralateral flank organ. Topical application of GLA to the testosterone-treated flank organ suppressed this testosterone effect. Other fatty acids such as saturated fatty acids, OL, elaidic acid, LA, ALA, AA and erucic acid, previously shown to inhibit the activity of 5-alpha reductase to a less significant extent than GLA, were much less effective than GLA. Topical treatment of hamster flank organs with DHT also stimulated the growth of the organ. This DHT-dependent activity, however, was not significantly affected by GLA, suggesting that flank organ growth is dependent on DHT and that GLA acted by inhibiting 5alpha-reductase. With intact male hamsters, the endogenous androgen-dependent growth of flank organs was also suppressed by topical treatment with GLA. The effect of GLA was localized at the site of application and did not affect the androgen-dependent growth of other organs such as testis, epididymis, seminal vesicle, and prostate in the hamsters. The authors concluded that GLA, with low toxicity and absence of any systemic effects, may be potentially useful for the treatment of androgen-dependent skin disorders. Bioriginal Food & Science Corp. © 1999

Ciao xxxxx. Ho seguito la discussione interessante sull'opportunita' di utilizzare anche l'estrone solfato nella terapia anti-calvizie: confermate che potrebbe darmi dei buoni risultati (almeno a livello teorico) e che soprattutto non da' effetti colletarali, specialmente femminilizzanti? Ed infine: conoscete qualcuno che l'ha usato e che ha avuto buoni risultati? Ciao

SCusa Tigre se ti ho fatto tradurre tutto sto coso, ma avevo capito da come si era sviluppata la discussione su alt.baldspot che nei prossimi 5 anni sarebbe uscita la cura definitiva. Chiedo venia, anche perche' avrei un altro paio di studi che reputo interessanti da postare...

Ciao Tigrotto, ho un regalino per te: una traduzioncella facile facile! Puoi? The (MPB) Follicle Doesn't Die: "The good biological news is that in the most common types of thinning, hair follicles don't die. In classic male- and female-pattern hair loss (androgenetic alopecia), for instance, follicles become miniaturized and their growing phase abbreviated; they then produce extremely short, fine hairs. 'Even guys who are bald still have little hairs on the top of their head,' explains Bruce. A Morgan of Harvard's Cutaneous Biology Research Center." (MS) p. 76 "Hair thinning generally happens not because follicles disappear, but because the ratio of follicles in the growing and non-growing phases shifts unfavorably. Also, many follicles in balding people shrink progressively, ultimately producing only small, colorless hairs." p. 74 "Baldness often arises not because follicles die but because they shrink and malfunction. Drugs that manipulate Wnts or other regulatory proteins might one day protect threatened follicles and prod shrunken ones into producing hair normally again." p. 72 "Last year Ronald G. Crystal of Weill Medical College of Cornell University found that when hair follicles in adult mice are induced to make the protein during the resting, telogen stage, the follicles shift prematurely into the hair-producing, anagen stage. Thus, sonic hedgehog can stimulate dormant follicles to begin producing hair." p. 79 "As researchers become more sophisticated in their knowledge of the molecular interactions underlying hair growth, they can begin animal testing of compounds that might restore order to deranged regulatory pathways and revive dormant follicles." p. 79 Research Highlights: "To trace the molecular controls over any given process, scientists first need to know the basic outlines of the process itself. By 1995 microscopists and others had developed a good sketch of the incredible steps that lead to the formation of hair follicles in the developing embryo. The had also described the hair cycle -- the periodic phases during which follicles produce or stop producing hair; follicles undergo this cycle repeatedly in a lifetime." p. 72 "Anagen follows telogen. Early on some of the stem cells from the bulge divide and travel down along the basement membrane to become matrix or outer root sheath cells. Once formed, the matrix cells proliferate and ultimately give rise to the hair cells and the inner root sheath, repeating the steps that occur during the embryonic development. This repetition implies that the events of anagen are probably controlled by a number of the same signaling molecules that operate during development." p. 74 "As is true during follicle development in the embryo, during the anagen signals from the dermal papilla instruct the matrix cells to divide and subsequently differentiate into hair cells. For this reason, scientists have become very interested in uncovering the nature of the signals issued by the dermal papilla during development and cycling. They don't have the answer yet, but in the past few years Elaine Fuchs and her colleagues at the University of Chicago have discovered that the dermal papilla's signals probably convey their directives largely by activating still other signaling molecules -- members of the Wnt family of proteins. Wnt proteins have long been recognized as key regulators of varied developmental processes in mammals and other organisms." p. 74-75 "Fuchs began her search for the molecules that dictate the conversion of matrix cells to hair cells by trying to identify the molecules in the nucleus that switch on the hair keratin genes. In 1995 her group discovered that a regulatory protein called lymphocyte enhancer factor 1 (LEF1) participated in activating the hair keratin genes. It was also present during hair follicle formation in the embryo, where it appeared in the earliest clusters of ectoderm cells as well as in the cells destined to form the dermal papilla." p. 75 "...without LEF1, mice fail to make a furry coat. And when Fuchs's team engineered mice that produced excess LEF1 in the skin, the animals produced more hair follicles than normal." p. 75 (you've all read that online article, I'm sure -- http://news.bbc.co.uk/hi/english/sci/tech/...1000/221359.stm -- Trey) "LEF1 cannot activate genes on its own; rather it must first couple with a second protein, beta-catenin. The only mechanism known to trigger this coupling was the activation of the signaling cascade that begins with the binding of a Wnt molecule to the cell surface. Beta-catenin normally helps to form junctions with neighboring cells. In the absence of Wnt signaling, an enzyme inside the cells marks any unused beta catenin for destruction. Wnts instruct cells to handcuff that enzyme. With the enzyme out of commission, beta-catenin becomes free to accumulate and to pair with LEF1 or one of its relatives." p. 75 "Those experiments implied that Wnt is the mesoderm-issued signal that instructs the overlying ectoderm to begin forming an appendage and is likewise the ectodermal signal that tells the underlying mesoderm to form the dermal papilla. What is more, much later in development, after follicles have formed, Wnt appears to be the message that directs matrix cells above the dermal papilla to differentiate into hair cells." p. 76 "As adults, these rodents [mentioned earlier -- Trey] acquired an unusually lush coat by forming new follicles between the ones that were laid down during the embryonic development... As the furry rodents aged, they acquired benign lumps that resembled a common human scalp tumor called pilomatricoma. Fuchs's laboratory subsequently demonstrated that in humans these tumors arise when a mutation in the beta-catenin gene prevents the protein's breakdown." p. 77 "Wnts are major regulators of follicle development and cycling but...simply delivering Wnts by constant application would not be feasible as a human therapy, because of the tumor risk. The trick to correcting hair maladies, Fuchs contends, may be to deliver Wnts in a pattern that mimics nature better or to manipulate other steps in the Wnt signaling cascade." p. 78 [if other tests go well...] "...human scalp skin can be transplanted onto mice incapable of rejecting it to determine whether human and mouse follicles respond comparably to the agents. And if those results are good, investigators may attempt human trials of the most promising drug candidates." p. 79 The Outlook: "'We don't have a product yet that's going to be 'wow!' for over 50 percent of people she [Marty Sawaya] notes. I do think dutasteride will be that product if the company goes forward.'...GlaxoSmithKline may choose to pursue it first as a prostate drug, as happened with finasteride." p. 77 (MS) "Scientists are on the prowl for new drugs all the time....Michael Detmar discovered earlier this year that abundant amounts of a growth factor that increases the blood supply make mice grow hair faster and thicker. Now...the hunt is on for small molecules that will either mimic or activate the factor." p. 77 (MS) "A fundamental understanding of hair biology may someday let physicians replace a defective gene in hair follicles through gene therapy or grow hairs in a petri dish for use in graft surgery. 'The complexity of the question is like understanding how a limb forms. It's ambitious. But we are discovering a lot and discovering a lot quickly,' muses Kurt S. Stenn, chief scientific officer of Juvenir Biosciences, a company recently spun off from Johnson & Johnson to focus predominantly on hair research. 'This is a wonderful time to be working in hair biology. So many breakthroughs are coming.'" p. 77 (MS) "No one can predict how soon dermatologists and pharmaceutical companies will be able to produce new therapies built on the discoveries emerging from basic research into hair follicle development and cycling. But that research is progressing remarkably fast. If the pace continues, Fuchs predicts, much of the information that is needed to understand the complex controls on hair manufacture will probably be in hand within the next five years." p. 79

Aggiornamento: prendo due volte a settimana saw-palmetto + ornitina che ho ordinato dallo shop del sito. Da giugno comincero' a mettere una volta a settimana anche qualche goccia di Aloe.

Dep, puoi mandare anche a me il foglietto illustrativo?