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boh81

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  1. ma si trova facilmente in farmacia?
  2. boh81

    Cosa ci resta??

    quote: Aperto da BIONDO82: boh dovresti dormire la notte no!
  3. boh81

    Cosa ci resta??

    mal che vada ci resta il rasoio o la lametta
  4. boh81

    Vit. B6 e Zinco Solf. per i Docs

    dottore cosa dice si può provare? la quantità di zinco è bassa poi assunta per via topica non causa alcun problema giusto?
  5. tranquilli ci sono ancora! scusate l'orario, ma ho fatto una serata allora prima di tutto non ho abbandonato il mio regime, ho solo iniziato coi massaggi, visto che prima non prendevo niente! Cmq non saprei dire a livello di ispessimenti vari, ma ultimamente controllando vedo che dei vellusini prima piccini piccini stanno diventando un po piu grossi....magari è solo impressione...però ne vedo anche un po di piu che dire...non so se c'entra, magari sarebbero rispuntati lo stesso...però continuare che costa? ah devo aggiungere che da un mesetto applico anche la nivea for men consigliata sui forum usa....rende lo scalpo ottimo!
  6. boh81

    wow!

    http://appft1.uspto.gov/netacgi/nph-Parser...+catenin"+AND+ wnt&RS="beta+catenin"+AND+wnt The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided. beh qui almeno sappiamo che c'è una patente
  7. boh81

    Cosa ci resta??

    http://appft1.uspto.gov/netacgi/nph-Parser...+catenin"+AND+ wnt&RS="beta+catenin"+AND+wnt
  8. boh81

    Mi ritiro

    eh io gli ho scritto 2 volte ma non mi rispondono! se qualcuno ha il fax mi sa che è meglio!!
  9. boh81

    Vit. B6 e Zinco Solf. per i Docs

    si ma nel forum hlh hanno buoni risultati anche senza ormoni...
  10. boh81

    Mi ritiro

    xxxxx scusate era solo uno sfogo... sono già tornato, piu forte di prima...e ho già chiesto alla farmacia legnani di prepararmi zinco+b6...se qualcuno vuole aggregarsi facciamo un mega-ordine! alla fine ricordiamocelo...mal che vada rimarremo pelati....mica si muore!
  11. boh81

    News Sui PEPTIDI

    macchè calvi....sarebbe il meno devono MORIRE bruciati!
  12. boh81

    Vit. B6 e Zinco Solf. per i Docs

    beh ho sentito dire di studi che dimostrano che zinco + b6 abbassano quasi del 100% il dht nello scalpo..... qualcosa non mi è chiaro The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.
  13. boh81

    Mi ritiro

    xxxxx sto per prendere questa decisione.....a dire il vero non è una vera decisione, visto che non sto utilizzando alcun prodotto.. Il problema è che tutto questo mi sta facendo perdere di vista le cose veramente importanti della vita...non posso passare ore a studiare quale prodotto riuscirà forse ad allungarmi l'agonia... Il fatto è che sto da poco con una ragazza, potrebbero essere forse i giorni piu belli della mia vita, ma li sto rovinando pensando ai capelli. Quando sarò vecchio non vorrei ripensare alla mia giovinezza e ricordarmi solo davanti allo specchio a guardarmi i capelli...capite? Il morale va su e giu, in alcuni casi mi sono "svegliato" dal momento no pensando : ma sei scemo? guarda come stai trattando la gente che ti vuole bene..... non lo so, probabilmente è solo un periodo no, spero solo che in futuro potrò tornare ad essere il ragazzo allegro e sempre disponibile che ero fino a poco fa, coi capelli o senza.
  14. boh81

    News Sui PEPTIDI

    spero solo che un giorno ci possa essere la giusta punizione per la gente che si prende gioco delle sofferenze altrui....
  15. boh81

    News Sui PEPTIDI

    hanno tolto la pagina del sab....praticamente dove c'erano tutti i dottori tra cui anche Hisia o come si scrive a sto punto è una farsa al 99,9 %
  16. boh81

    News Sui PEPTIDI

    The Board of Directors has accepted the resignation of certain SAB and Management positions and is in a period of reorganization. This reorganization period will be abbreviated, in part, by the extensive experience of our upcoming pharmaceutical partner. This page will be updated at the appropriate time. ahahhahahhahha ******** !
  17. boh81

    FLURIDIL

    "Until we have established our presence on these markets, we regret that we cannot ship any Eucapil outside of the Czech Republic." però magari per salus uno strappo alla regola lo fanno....
  18. boh81

    FLURIDIL

    http://www.interpharma-praha.com/html/spec...uridil_text.htm FLURIDIL, A NOVEL DERMO-COSMETIC AGENT FOR TOPICAL APPLICATION IN ANDROGENIC HAIR LOSS, i.e. EFFLUVIUM AND ALOPECIA Fluridil as a 2% solution in isopropyl alcohol (Eucapil®), in 2 ml ampoules for daily use, has been approved as a cosmetic/hair care product in the Czech Republic. Interpharma is actively working on an introduction into other countries. Until we have established our presence on these markets, we regret that we cannot ship any Eucapil outside of the Czech Republic. Our lives depend on our hormones. Of those, the sex hormones, estrogens in women and androgens in men, are of major importance on influencing almost every aspect of our physiology and social life. The sex hormone levels physiologically change with age. Thus, after levels of testosterone and its much more potent derivative, dihydrotestosterone (DHT), peak in the twenties, a continuous decline is observed throughout the remainder of life. In women, estrogen levels peak in their twenties, and then slowly decline until menopause, where the drop is sometimes drastic. Women also produce some male sex hormones and inversely, men produce estrogens, initially in very small quantities, but with years the levels increase until around 60, women actually produce about as much male sex hormone as men at that age. As it happens, it is the male hormones which are responsible for the most usual form of hair loss in both men and women. The relationship between the sex hormones and the scalp hair is not yet fully understood. Early in life, estrogens in women and androgens in males make scalp hair grow. Then, usually after 30, for reasons not yet explained, in genetically predisposed males the androgens start pushing the hair out of the follicles, thus causing hair loss. A similar phenomenon occurs in women who have reached a stage in their life when they also produce substantial levels of androgens. Hair loss, which dermatologists call effluvium, ultimately results in alopecia. There are also other reasons for alopecia which dermatologists diagnose and often can treat, but by far the most prevalent is alopecia caused by the male hormone and therefore called androgenic. Testosterone by a small chemical modification normally occurring in the body changes into an analog, the so-called dihydrotestosterone (DHT). As an androgen, this compound is much more powerful. One approach to the treatment of hair loss, therefore, has been to inhibit this conversion by a drug. Such a drug has been developed and is currently marketed as Propecia. The effectiveness of Propecia has been reported as varying from 30-50% in arresting hair loss, but clearly there is a disadvantage of a chronic systemic administration and the uncertainty of what changing basic physiological mechanisms may cause. Although there are no such indications in the current clinical studies, no one is certain what manipulation of the normal hormonal turnover in the body will produce after extended use. It has always been obvious to researchers that an agent acting only on the skin and not penetrating into the body would be much preferable for prevention of hair loss and/or restoration of hair growth. There have been countless attempts to achieve this goal. One drug originally developed to decrease blood pressure, minoxidil, was found to induce upon longer use some hair growth, but only in the vertex area. The efficacy was reported as somewhere around 30%; the effect was attributed to a number of factors, most prominently an incidental increase of blood flow in the scalp. Various vitamins, plant extracts and other preparations were also developed, but none really could overcome the essential effect of the male hormones affecting the hair follicles. It has been known for a long time that the male hormones can act only after attaching themselves to a messenger, a small protein, the so-called androgen receptor. The androgen receptors can be blocked by certain drugs. These were developed for therapeutic purposes, among others, to keep in check the cancer of the prostate, which squarely depends upon the androgen hormones for its growth. These compounds are given orally and are resorbed from the gut. They act directly by blocking the androgen receptor. It should be noted that such inactivation is always temporary since the cells of our body in their daily cycles continuously manufacture the androgen receptor. Further, there is the problem that androgen receptors are distributed throughout our bodies and are also copious in the brain, where their blockade invariably induces loss of interest in matters of sex, i.e., loss of libido. When applied on the scalp these drugs either had no effect or they were resorbed and passed into the body eliciting systemic side effects. This is why none of these drugs were developed into a safe dermo-cosmetic product to combat hair loss. In an effort to develop a more powerful inhibitor of the androgen receptor, the biomedical laboratories Biophysica in California, in collaboration with the research laboratories of a Czech biotech pharma company, Interpharma Praha, developed a new class of substances which proved to render the androgen receptor inactive in a novel way. A large number of new molecules were synthesized and tested. Some were not resorbed when given orally or topically. The most promising molecule was structurally modified so that minor amounts of water would cause the molecule's decomposition, thus rendering it pharmacologically inactive and incapable to act inside the body. To prove that this substance, now called Fluridil, once resorbed into the skin would not enter into the body, a number of experimental studies were conducted using rats and rabbits, who are capable of taking up substances through their skin 6 to 10 times more than humans. We applied large quantities of Fluridil, far surpassing the highest conceivable dose in humans. Using sophisticated equipment of high sensitivity no trace of Fluridil or its fragments were ever found in the blood. Many studies were conducted to ascertain the systemic and topical toxicity in animals and finally in human volunteers at the specialized Experimental Dermatology Institute of the University of California in San Francisco, under the leadership of Professor Howard Maibach. The result of this study was remarkable in that no irritation whatsoever was observed, thus confirming the data we previously gleened from experimental animals. By then, news had spread and several of our colleagues of ours on their own started applying the compound to their scalp, soon to report the unusual efficacy of the alcoholic solution of Fluridil. We have thereafter optimized the composition of the solution, conducted all required safety tests and after having presented our findings to the authorities, gained marketing approval in the Czech Republic. In a study with human volunteers, not even trace levels of Fluridil were detected in the serum; therefore, it cannot be expected to have systemic effects. This was also confirmed by the clinical study conducted presently at the Medical School dermatology department (Chairman: J. Bucek, M.D., Palacky University, Olomouc, Czech Republic): in most subjects, increase in anagens (growing hair) and decrease in telogens (dying hair) after 3 months of daily application of 2 ml Fluridil was substantial; there were no changes in the hematological and hormonal profiles and there were no adverse effects. From what has been said above, it is obvious that the mechanism of Fluridil as a dermo-cosmetic device is sufficiently clear to judge Fluridil's prospective usefulness. Surely, when hair has been missing from the scalp for a long time and the hair follicles were obliterated by the ingrowth of connective tissue, there is very little chance for growing new hair. Here only transplants can reasonably work. Fluridil is therefore useful only when the hair follicles are still active and their androgen receptors are still intact. So far, the most successful findings were reported by volunteers who started using Fluridil at the time when the first loss of hair was encountered. With men, this can start any time after 30 years of age; with women very often the hair effluvium sometimes dramatically and suddenly appears concurrently with menopause. In these clients we find that the hair loss ceases after a few weeks of once-a-day application. Perhaps, unfortunately, but understandably based on what had been said above, in order to keep the androgen receptor in check it is necessary to continue applying Fluridil daily. In a number of volunteers we found that after some 3 to 4 months of use, new hair growth, "peach fuzz" - the appearance of baby hair - was induced in the scalp, unless it had been hairless for many years. With time and patience which the hair growth cycle requires - and which may be as long as one year - we often observe a gradual transformation of the "baby hair" into hair of normal appearance.
  19. quote: Aperto da boh81: io sto provando il metodo di calvino da 5 settimane....senza nessun altra terapia... 9 settimane....mi sa che sono l'unico tester....senza pagare 500 dollari!
  20. boh81

    News Sui PEPTIDI

    Sembra che la tecnologia non sia neanche loro....sarà una spiegazione per tutta questa riservatezza? Beh l'importante è che ci sia....anzi, a questo punto meglio se a produrla sarà qualcuno un pò piu affidabile no?
  21. boh81

    News Sui PEPTIDI

    TRADUZIONE Sembra un interessante coincidenza. Alla fine della pagina c'è uno dei loro progetti Studi sul meccanismo molecolare delle interazioni peptidi-lipidi usando biosensori interattivi, spectroscopi e procedure di modellamento (?!) molecolare. Applicazioni nel design di nuovi peptidi ormonali e antromicrobali (!?) e regolazione di ricettori G-protein-coupled (Dr M. Aguilar, & Dr W Thomas (Baker Medical Research Instititute)). E la WSMR dice questo di Kenneth Skinner nullKenneth Skinner, Ph.D., Biochemist and G-Coupled protein receptor field. Ma io non ho visto alcun documento pubblicato dal Dr Skinner..è molto inusuale almeno per un PhD non aver pubblicato documenti relativi ma essere esperti di un settore... Scusate gli errori nei termini tecnici, evidentemente devo studiare ancora un pò per la laurea
  22. boh81

    News Sui PEPTIDI

    interessante post di farrel (webmaster di hlh): http://www.med.monash.edu.au/biochem/resea...ts/peptide.html Hmmm thats an interesting coincidence. At the bottom of that page one of their future project is. Studies on the molecular mechanism of peptide-lipid interactions using interactive biosensors, spectroscopic and molecular modelling procedures. Application in the design of novel hormonal and antimicrobial peptides and G-protein-coupled receptor regulation (Dr M. Aguilar, & Dr W Thomas (Baker Medical Research Instititute)). And WSMR says this about Kenneth Skinner Kenneth Skinner, Ph.D., Biochemist and G-Coupled protein receptor field. But I have not seen any papers published by Dr Skinner which is unusual to say the least for PhD not to have any published papers but to be an expert in a field like that.
  23. boh81

    ossido di zinco

    si ma non ho nessuna pompetta ...
  24. boh81

    News Sui PEPTIDI

    Dear Sir: Being a new company, it is quite difficult to manage all the day to day operations at this time and the attorney reserved the name but did not file the proper paperwork within the necessary time frame. This is in the process of being corrected. My appology if this has caused you or your peers a lack of confidence in our company. I can assure you that our research is quite real and we have full intentions of bringing our products through the proper testing and to market if possible. Best regards, Darren Green, WSMR (and here was my e-mail to them yesterday): Dear Sirs: There has been a ton of concern, speculation, and talk regarding the authenticity of your firm, WSMR. Right down to the postings on "Hairlosshelp.com" about a "dissolving" of WSMR. The two-thousand of us on that forum have also heard (thanks to permission by WSMR granted to one of our posters who is involved in your study) from one who has said that we should continue to believe that this research is real, and continue to be patient.
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