Parliamo Di Questo...

[Scoiattolo]

Ketoconazolo e finasteride nel trattamento della AGA

 

Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA.

 

The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished.

Ketoconazole has been clinically shown to be effective in the treatment of AGA.

In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.1: Med Hypotheses.

[Emulat]

se ho capito qualcosa di come funziona il DHT, non è per niente positivo esserne completamente inibiti!

xxxxx è pur sempre un ormone maschile che ha anke altri effetti sul nostro corpo, non solo quelli negativi, quindi...

 

Riguardo questo shampoo super inibitore c'ho i miei sacrosanti dubbi :rolleyes: