Dr. Jahoda and Dr. Christiano - Identificazione di geni sull

[Lottatore]

Riporto un articolo interessante su un'identificazione di geni direttamente analizzati sulla papilla germinativa.

 

il Dr. Jadoha e' uno dei pionieri della hair cloning, mentre la Dr. Christiano e' forse la piu' prolifica e promettente ricercatrice su genetica e alopecia di tutto il mondo; e' lei ad ever scoperto il gene hairless nel 1998 relativo all'alopecia universalis. Emozionalmente il suo lavoro affascina, in quanto lei stessa e' stata affetta da 8 chiazze di alopecia areata.

 

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Abstract TITLE: Dermal papilla specific genes identified by microarray analysis AUTHORS (ALL): O'Shaughnessy, Ryan 1; Jahoda, Colin 2; Christiano, Angela 1 INSTITUTIONS (ALL): 1. Dermatology and Genetics and Development, Columbia University, New York, NY, USA; 2. Biological Sciences, Durham University, Durham, , UK;

 

ABSTRACT BODY: Abstract Body: At the base of a cycling vibrissa (whisker) follicle there are two distinct mesenchymal populations, the dermal papilla (DP), which is thought to provide the signals required to produce hair growth, and the dermal sheath cells (DS), a closely biologically related, yet distinct tissue whose function is largely unknown. In rodents, the dermal papilla retains the ability to induce new hair follicle production, while the dermal sheath does not have this inductive capability. We believe that the differences in gene expression between these two specialized mesenchymal tissues will shed light on their functions in morphogenesis and the continued cycling of the hair follicle. We compared microdissected intact DP and DS from the vibrissae of male brown Norway rats using Affymetrix genechips of over 8000 genes. Of the 8000 genes on the chips, only 800 were present in both tissues. Of these 800, only 30 were differentially expressed. Further validations steps by RT-PCR revealed that of these 30 genes only 8 were specifically expressed in the DP and not in the rest of the hair follicle. Of interest among these 8 genes were 4 secreted genes, 3 of which have been shown to inhibit extracellular proteases – including the known dermal papilla marker Nexin 1. Two of the inhibitor of DNA binding (ID) family of genes were also identified. We show that the secreted genes show variation of expression during the hair cycle of the vibrissa, and that a novel gene, a homologue of the gene mutated in bone dysplasia sclerostosis is preferentially expressed in DP. We conclude that there are indeed genes specifically expressed by the DP and that microarray analysis of freshly dissected tissue is a viable approach to detect such genes.

[Salusmaster]

Davverto interessanti questi studi;

complimenti Lottatore!

 

Facciamo in modo di tradurli e pubblicarli sul sito in italiano al più presto

 

grazie ancora!

[boh81]

This is probably the beginning of the most exciting era in hair loss treatment. A rare hair loss gene is discovered by geneticist Angela Christiano in the U.S. This is the first time ever that a specific gene is associated with hair loss in human. The gene is appropriately named "HAIRLESS".

Plagued by the devastating experience of hair loss herself, Ms. Christiano started on a mission to find a cure for hair loss back in 1996. Ms. Christiano's research led her to a family in Pakistan in which all of the family members are suffering from alopecia universalis - a rare form of hair loss that cause complete baldness in a person's scalp and eyebrows etc. Incidently, after a series of DNA testing on the Pakistani family, Ms. Christiano hypothesized a link between the Pakistani family and a batch of mice that were born hairless and eventually led to the biggest discovery in the history of hair loss treatment.

Ms. Christiano's discovery now make possible the study of how a specific gene dictate the life cycle of hair and what governs hair follicle's life and death. Hopefully, this will lead to the discovery of other hair loss related genes.

Ms. Christiano cautioned that the discovery of the "HAIRLESS" gene is only the first step. There are numerous genes out there for different types of hair loss and it will take years of research and clinical testing before something more concrete can be established. Also, the "HAIRLESS" gene is specific to alopecia universalis only. We have yet discover a gene that is related to the most common type of hair loss in humans - male pattern baldness. Nonetheless, the discovery is major advance in understanding the genetic causes for hair loss.

Ms. Christiano's discovery is also extremely inspiring for companies such as Johnson & Johnson which has recently started gene research for hair loss treatment. Currently, many hair loss treatments are hormonal based and carry undesirable side effects. For example, the new anti-baldness pill Propecia causes loss in sex drive in about 2% of the participants and can result in birth defects in women. According to Ms. Christiano, gene therapy for hair loss will carry little or no side effects and can be used by both men and women.

The discovery has sparked so many interests that a company in California claimed that if a gene that stimulates hair growth is found, it has the technology to delivery that gene to empty hair follicles and grow hair. In fact, Both AntiCancer Inc. in San Diego and Applied Genetics in New York are currently researching some kind of gene therapy for grey hair or hair loss. AntiCaner Inc. already had spectacular results in hair coloring using gene therapy. The treatment involves applying some kind of cream onto the skin. The cream is made up of "liposomes", a compound that functions as the delivery mechanism which transports the appropriate gene or pigmentation to the roots of the hair. The treatment is relatively effective and there is no known side effects at this point. However, the treatment needs to be reapplied every two to three weeks. As of now, the product is not available for commercial use yet. Scientists are still researching and designing the "optimal" liposomes for the treatment to be fully effective. Presently, a large amount of genetic materials are required for the procedure to be effective and as a result, each treatment is very expensive. It is expected that the treatment will be available for commercial use in about 2 - 5 years.

 

QUESTA COSA è DEL 1998. come mai non se ne sa piu niente? sono passati 4 anni.....comincio anch'io a credere che la soluzione ci sia già da tempo.....

 

[rokie79]

in poke parole ke c'è skritto???

[boh81]

Praticamente che ha trovato un gene associato alla calvizie. Parallelemente molte multinazionali stanno lavorando su questo e sulla scoperta di una cura.

Dice anche che un paio di società hanno già pronto il trattamento, per la calvizie e la cura dei capelli bianchi. Il trattamento consiste nell'applicare una crema sullo scalpo...e andrebbe ripetuto ogni 2-3 settimane (!!!! ). La crema è fatta di liposomi che dovrebbero trasportare il corretto gene o pigmentazione alla radice del capello.

 

Al momento ci vuole un sacco di materiale genetico perchè la terapia faccia successo,e questo è molto costoso. Si attende l'uscita in commercio di un trattamento entro 2-5 anni

[rokie79]

meeeeeeeeee sarebbe la kosa + bella del mondo. cmq grazie e prendi un voto

[sayan4]

Scusate ma allora non mi trovo.Se il documento e del 98,sarebbero passati 4 anni,e non si sente parlare di niente di tutto questo.E una vbufala anche questo??

[boh81]

eh infatti era quello che volevo dire...... a meno che uscirà qualcosa a sorpresa un giorno o l'altro!

[napoleonebonaparte]

ma secondo voi non potrebbe trattarsi dei famosi flex?Vero è che non si tratta di materiale genetico,però da quanto ho capito io-il che non è garanzia di nulla,anzi-sempre di trattamento topico si tratta....

Ciao a tutti!!!