Spironolactone (X Dott. Gigli)

[Ciccio79]

Salve,

facendo una ricerca sul forum ho trovato che lo spironolactone sarebbe un potente antiandrogeno indicato per via sistemica solo nelle donne.

A seguito di una mia ricerca su internet mi risulta che invece lo spiro venga usato per via sistemica anche negli uomini come blando diuretico.

Dove sta la verità? E' possibile per gli uomini assumere sistemicamente spiro?

Grazie

[Bellicapelli]

Ciccio,

non ti azzardare ad assumere sistemicamente lo spironolattone!!!

 

Assunto per via orale può avere effetti femminilizzanti nell'uomo (ad esempio ginecomastia)!

 

Mi raccomando

[Gigli]

No gli uomini non possono assumere spironolattone per os almeno alle dosi abitualmente terapeutiche.Comunque c'e' chi lo usa a bassissimo dosaggio.Io personalmente sconsiglio.

 

Saluti www.drpaologigli.it

[Ciccio79]

Salve,

riporto qui le indicazioni riguardo spiro, non mi sembra di vedere controindicazioni riguardo l'assunzione da parte di uomini...mi sfugge forse qualcosa?

Inoltre viene venduto come leggero diuretico...com'è possibile?

 

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Basic Information

 

Habit forming? No

Prescription needed? Yes

Available as generic? Yes

Drug class: Antihypertensive, diuretic

 

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Uses

 

Reduces high blood pressure.

Prevents fluid retention.

Treats hyperaldosteronism, hypokalemia, polycystic ovary syndrome, female

hirsutism.

 

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Dosage & Usage Information

How to take:

Tablet--Swallow with liquid or food to lessen stomach irritation. If you

can't swallow whole, crumble tablet and take with liquid or food.

 

When to take:

1 dose a day--Take after breakfast.

More than 1 dose a day--Take last dose no later than 6 p.m.

 

If you forget a dose:

1 dose a day--Take as soon as you remember up to 12 hours late. If more

than

12 hours, wait for next scheduled dose (don't double this dose).

More than 1 dose a day--Take as soon as you remember. Wait 6 hours for

next

dose.

 

What drug does:

Increases sodium and water excretion through increased urine production,

decreasing body fluid and blood pressure.

Retains potassium.

 

Time lapse before drug works:

3 to 5 days.

 

Don't take with:

Any other medicine without consulting your doctor or pharmacist.

 

 

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Overdose

SYMPTOMS:

Thirst, drowsiness, confusion, fatigue, weakness, nausea, vomiting,

irregular heartbeat, excessive blood pressure drop.

 

WHAT TO DO:

 

 

Dial 911 (emergency) or O (operator) for an ambulance or medical help.

Then

give first aid immediately.

See EMERGENCY Information.

 

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Possible Adverse Reactions or Side Effects

Life-threatening:

 

In case of overdose, see Overdose section.

Common:

 

Drowsiness or headache, thirst, nausea, vomiting, diarrhea, abdominal

cramping, muscle cramps.

Infrequent:

 

Confusion, irregular heartbeat, shortness of breath, constipation, breast

tenderness, unusual sweating.

Numbness, tingling in hands or feet; menstrual irregularities; change in

sex

drive; dizziness; energy loss.

Rare:

 

Rash or itchy skin, fever.

 

*****Deep voice in women, excess hair growth, voice change, enlarged

clitoris in women.*****

 

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Warnings & Precautions

Don't take if:

 

You are allergic to spironolactone.

You have impaired kidney function.

Your serum potassium level is high.

Before you start, consult your doctor:

 

If you have had kidney or liver disease.

If you have diabetes.

If you have menstrual abnormalities or breast enlargement.

If you will have surgery within 2 months, including dental surgery,

requiring general or spinal anesthesia.

Over age 60:

 

Limit use to 2 to 3 weeks if possible.

Adverse reactions and side effects may be more frequent and severe than in

younger persons.

Heat or fever can reduce blood pressure. May require dose adjustment.

Overdose and extended use may cause blood clots.

Pregnancy:

No proven harm to unborn child. Avoid if possible. Consult doctor.

 

Breast-feeding:

No proven problems. Consult doctor.

 

Infants & children:

Use only under medical supervision.

 

Prolonged use:

 

Potassium retention with irregular heartbeat, unusual weakness and

confusion.

Talk to your doctor about the need for follow-up medical examinations or

laboratory studies to check blood pressure, kidney function, ECG* and

serum

electrolytes.

Skin & sunlight:

Increased sensitivity to sunlight.

 

Driving, piloting or hazardous work:

Avoid if you feel drowsy. Otherwise, no problems expected.

 

Discontinuing:

Consult doctor about adjusting doses of other drugs.

 

Others:

No problems expected.

 

 

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Possible Interaction with Other Drugs

GENERIC NAME COMBINED EFFECT

 

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ACE inhibitors*: Possible excessive

captopril, enalapril, potassium in blood.

 

Amiloride Dangerous potassium retention.

Anticoagulants*, Possible decreased

oral anticoagulant effect.

Antihypertensives*, Increased antihypertensive

other effect.

Aspirin Decreased spironolactone effect.

Carteolol Increased antihypertensive effect.

Cyclosporine Possible excessive potassium in

blood.

Digitalis Decreased digitalis

preparations* effect.

Diuretics*, other Increased effect of both drugs.

Beneficial if needed and dose is

correct.

Laxatives* Reduced potassium levels.

Lithium Likely lithium toxicity.

Nicardipine Blood pressure drop. Dosages may

require adjustment.

Nimodipine Dangerous blood pressure drop.

Nitrates* Excessive blood pressure drop.

Potassium iodide May raise potassium level in blood

to toxic levels.

Potassium Dangerous potassium retention,

supplements* causing possible heartbeat

irregularity.

Salicylates* May decrease spironolactone effect.

Sodium bicarbonate Reduced high potassium levels.

Sotalol Increased antihypertensive effect.

Terazosin Decreases effectiveness of

terazosin.

Triamterene Dangerous potassium retention.

 

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Possible Interaction with Other Substances

INTERACTS WITH COMBINED EFFECT

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Alcohol: None expected.

 

 

Low-salt milk. Possible potassium toxicity.

 

Cocaine: Increased risk of heart block and

high blood pressure.

 

 

Salt. Don't restrict unless directed by

doctor.

Salt substitutes. Possible potassium toxicity.

 

Marijuana: Increased thirst, fainting.

 

Tobacco: None expected.

 

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From the Complete Guide to Prescription & Non-Prescription Drugs by H.

Winter Griffith, M.D. © 1996 The Putnam Berkley Group, Inc.; electronic

rights by Medical Data Exchange

 

 

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[Ciccio79]

Tutto tace?

[Gigli]

Credo di aver puntualizzato bene qual'e' il problema e capelli idem. Se poi ci tieni a femminilizzarti fai pure.De gustibus

Saluti www.drpaologigli.it

[Ciccio79]

Dr Gigli mi scusi ma io mi chiedevo come mai, se gli effetti sull'uomo sono così devastanti, all'interno delle indicazioni terapeutiche del farmaco non vi sia traccia alcuna di controindicazioni specifiche per l'uomo...

Se potesse rispondere a questo le sarei molto grato, anche un "non lo so" sarebbe gradito.

La ringrazio...

[Gigli]

Allora non e' che sia proibito usare lk spironolattone nell'uomo ma lo si puo' solo in condizioni patologiche di fondo.Te ne cito solo una " la cirrosi epatica con encefalopatia porto sistemica" .In altre parole la nostra laurea in medicina serve anche a superare gli enigmi nascosti nei foglietti iullustrativi.Lo scopo per cui vorresti usare lo spironolattone tu e' assolutamente non indicato(anche nel foglietto illustrativo) e sconsgliato in maniera assoluta, che poi lo si possa anche.. usare nell'uomo in condizioni patologiche e' vero , ma non certo in una persona sana come presumo sia tu.

 

cari saluti

[Ciccio79]

Perfetto la ringrazio...