Cell Therapies per i Doc Gigli / Marliani

[Aragorn]

Volevo chiedervi se avevate visibilità di questa sperimentazione australiana o se avevate rilevato ulteriori informazioni a riguardo su qualche rivista scientifica.

I dettagli sono sul sito da cui allego un breve estratto:

http://www.uws.edu.au/sfh/sxxxch/

 

Grazie per la preziosa collaborazione.

 

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Hair Follicles of Skin

The control of the human hair follicle function. Premature loss of hair is a common cause for distress in men and women, affecting quality of life and leading to depression. Baldness results from a reduction in the functional activity of the scalp hair follicle population. The procedure currently available to ameliorate this condition is hair transplantation. Surgery is expensive, slow, regressive and requires anaesthesia. Our approach is hair follicle induction. This is a different approach, conflating what is known of the hair follicle with current expertise in tissue engineering.

 

2.1 Subprogram: Hair follicle neogenesis.

We have developed microsurgical procedures to isolate follicle inductive cells and culture methods to increase their numbers in vitro. Grafting of cultured cells to animal recipients have resulted in follicle neogenesis and hair growth. Our research has reached the development stage and have identified a commercial partner. The objective is to use molecular biology, transgenesis and bioreactor technology to launch cell therapies for hair replacement in humans.

 

2.2 Subprogram: Follicle stem cell-derived proteins.

Identification of inductive cell signalling factors will have profound implications for understanding hair thinning and hair loss in humans and is likely to impact on the production of animal fibres of commercial significance. Cell culture provides the opportunity of isolating inductive factors from cells and their medium. Simple innovations have permitted us to isolate bioactive molecules from follicle cells. This is the first time that reactive proteins has been reported from these cells. Since the inductive cells affect the rate of proliferation of the adjacent hair-forming cells, it seems likely that they will also affect hair growth. We plan to characterise factors produced by inductive cells and confirm that their expression alters hair fibre growth in model systems.

 

Publications:

Yardley, G., Relf, B., Isaacs, K., Lakshmanan, J. Reinshagen, M. and Moore, G.P.M. (2000). Expression of nerve growth factor mRNA and its translation products in the anagen hair follicle. Exptl. Dermatol. 9, 283-289.

 

Moore, A.G. and Moore, G.P.M. (2001) Extracellular matrix molecules and follicle morphogenesis in ovine skin. Reproduction, Fertility and Development 13, 143-149.

 

Wynn, P., Kent, W., Gulati, S. and Moore, P. (2002). The use of dietary sources of lipid protected from ruminal degradation and skin enzyme inhibitors to manipulate wool growth. Agric. Sci. 15, 31-34.

 

Thomson, M., McCarroll, J., Bond, J., Gordon-Thomson, C., Williams, E. and Moore, G.P.M. (2002). Parathyroid hormone-related peptide modulates signal pathways in skin and hair follicle cells. Exp. Dermatol. (in press).

[Gigli]

Molto interessante ma mi sembra ancora allo stato iniziale di sperimentazione.

 

Saluti www.drpaologigli.it

[matteo]

Scusa ma cosa c'è scritto esattamente...grazie

[Aragorn]

E' stato tradotto nel sito della HM