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Irreversibilita' della fibrosi dopo 30 mesi circa


Renato

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Irreversibility of hair follicle changes after 30 months of

Androgenetic Alopecia.

Konstantinova N, Korotkii N.G, Sharova N, Barhunova E, Gaevski D.

Nioxin Research Inc, Atlanta, USA

Moscow Medical University

 

We studied horizontal and vertical biopsy from 15 Caucasian 24-41 year

old males diagnosed with bitemporal recession Androgenetic Alopecia

(AA) for 1.5 –18 years (average 7.4 years). All 15 biopsies were

stained with H&E, Van Gsalus and with other collagen specific

stainings. 1. Eleven pts with AA longer than 3 years had

perifollicular fibrosis - collagen fibers were compact and formed a

small scar-like formation around each anagen hair follicle(HF). Two

patients - 33 year old with 18 month AA and 23 year old with 20 month

AA did not have these hair follicle changes. Two 26-year-old patients

with 30 and 36 month AA respectively were found to have some not so

severe collagen fiber changes. 2. Infundibulum of HF dilatated 124-192

mm and most of them covered with keratinazed plug lacking normal hair

shaft growth. 3. Decreased number of hair follicles 1.75-2,45 per sq.

mm from 3.5-5 per sq. mm in control group. 4. None of anagen HF was

situated in subcutaneous fat. We showed a correlation between length

of the AA and severity/ thickness of perifollicular fibrosis. The

result of this study is that any treatment of AA is recommended to

start earlier than 30 months from first signs of AA. This should

prevent irreversible collagen changes associated with “fibrotic

incapsulation” of most anagen HF in involved areas, which

usually leads to loss of normal blood supply, innervation, and

subsequent miniaturization and prevention of hair from normal cycling.

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