MORFEUS

Veramente credibili le ultime notizie sulla HM.... una piccola traduzione per chi non mastica l'inglese HAIRmultiplication patient results: The new hair growth as a result of HM treatment is totally natural and undetectable. It is impossible to tell that the test subject was a HM patient. There are no scars or anything unusual associated with the test patient's new hair growth. Hair direction is not an issue. Hair texture is not an issue. Hair color is not an issue. It is exactly like our normal growing hair. La ricrescita dei capelli dovuta alla HM è totalmente naturale e impercettibile,è impossibile riconoscere che un paziente è stato sottoposto alla HM Non ci sono cicatrici e niente di inusuale che non rispecchi la naturale ricrescita. La direzione dei capelli non è un problema La struttura del capello non è un problema Il colore del capello non è un problema E' esattamente come la nostra naturale ricrescita

Geronimo, Tesauro sarà anche il piu' bravo chirurgo italiano.. e allora? per questo non posso parlare in modo diretto scrivendo quello che penso?parlo a lui come parlerei a un metalmeccanico o al papa..meritano tutti ugual rispetto..o lui è superiore? ..continuo a sostenere che la cicatrice dietro la nuca è un brutto danno irreversibile e continuo a sostenere che bisognerebbe cambiare tecnica e imparare la tecnica del dott. Woods. Non sono un medico, sono solo uno che dice quello che pensa sensa formalismi inutili..

Can you give us a more precise estimate as to when HM will become available in the Netherlands and the rest of the world? How much sooner will Hair Multiplication become available in the Netherlands than in other countries ? Somehow I got the feeling that people in your forum will not be satisfied until I give you the exact date, month and year. An estimate is after all a projection based on what I know at the moment. I am not sure how much further I can refine the estimate for your group. All I can tell you is that based on what I know at this very moment, the projection I gave you last year is still a realistic target. I hope you understand that there are many variables or unknowns in medical research. What I gave you was simply a projection. I certainly do not want any of your group members to come knocking on my door exactly 5 years from the date of our last meeting. Nobody can be that precise when it comes to medical research. At this very moment, I still think that the estimate I gave you last year is realistic but please do not regard this as a guarantee. We keep hearing from people in HairSite's forum that HM will be available in two years, do you agree with that? HM will definitely be available in The Netherlands much sooner than the rest of the world. My team is working very hard to make this happen and if everything goes well, it will be available in The Netherlands sooner than the estimate I gave you last year. I hope it will be "APPROXIMATELY" two years, but again this is not a guarantee. It can be 2 years or 3 years. I cannot offer anything more precise at this point. I hope you understand. What is the probability that HM will not be available in the next 4 years? Very unlikely unless something very radical happens. The procedure and technology is actually available now at my clinic. But to make this a commercial application for the general public, I need to further refine the process. Most of us understand that you have certain consistency issues with HM. Quite honestly, many of us would be very pleased to settle for a varying degree of density ranging from 20% - 80% as a temporary solution. So why wouldn't you consider bringing HM to the market now and then perfect the procedure as we progress? Is the decision of not bringing HM to market now a personal reason or are there external factors that prohibit you from doing so? It's both. Personally, I do not wish and I don’t think it’s ethical to roll out a new treatment when patients are unable to get consistent results. You are actually creating more problems than solutions by introducing a treatment that is not ready for everyone. Also, it would help tremendously in expediting regulatory authorities' approval process in different countries when the clinical trials show consistent results throughout. Do you think that health professionals other than surgeons and dermatologists will learn to do HM and thereby increase HM's availability? Not likely. It is important to be selective in screening medical professionals who are interested in learning HM from my clinic to make sure that the treatment is delivered to the patients in the most professional manner possible. Will the clinic in the Netherlands be accepting foreign patients ? Yes. As a matter of fact, all our existing patients worldwide will be notified as soon as HM becomes available. Would that be unfair to other patients if you give preference to existing patients ? We anticipate an overwhelming demand for HM from patients worldwide the moment it becomes available. Giving existing patients priority will make the situation more manageable as the clinic expands over time to accommodate the demand. HM patients are expected to be treated one at a time with proper care, attention and not to be rushed in and out of the clinic like an assembly plant. Since all existing patients had already been examined personally by me and their personal information are already set up in my clinic's database, a lot of the administrative hassles can be substantially reduced by attending to existing patients first. Do you have plans to include Canada when HM eventually become available? Yes, absolutely. Will HM be required to be approved by an European authority besides the one in The Netherlands and how long will this approval process take? Yes and No. HM is a medical procedure, but the procedure itself does not have to be approved. The materials as well as the (electronic) instruments requires approval from the respective authorities in different parts of the world. And also, for certain phases, we have to follow several rules and regulations. As a general rule, the approval process for the rest of Europe should be faster than approval from the FDA. In the event that HM would be released in The Netherlands before the U.S., would a person holding an American or Canadian passport be denied access to HM treatments? Unless I misunderstood your question, but I do not see why that would be an issue. We already have many patients from the U.S seeking Follicle Transplantation procedure here at my clinic.

All HAIRmultiplication Questions At A Glance A Total of 62 Questions in 13 Categories answers on the next page, follow instructions at bottom of page Availability | Candidates | The Procedure | Competition | Cost | Density & Results | Hair Transplantation | Trials & Test Patients | ISO Certification | Technical | Legal Issues | Media | Other | AVAILABILITY Can you give us a more precise estimate as to when HM will become available in the Netherlands and the rest of the world ? How much sooner will Hair Multiplication become available in the Netherlands than in other countries ? We keep hearing from people in HairSite's forum that HM will be available in two years, do you agree with that? What is the probability that HM will not be available in the next 4 years? Most of us understand that you have certain consistency issues with HM. Quite honestly, many of us would be very pleased to settle for a varying degree of density ranging from 20% - 80% as a temporary solution. So why wouldn't you consider bringing HM to the market now and then perfect the procedure as we progress? Is the decision of not bringing HM to market now a personal reason or are there external factors that prohibit you from doing so? Do you think that health professionals other than surgeons and dermatologists will learn to do HM and thereby increase HM's availability? Will the clinic in the Netherlands be accepting foreign patients ? Would that be unfair to other patients if you give preference to existing patients ? Do you have plans to include Canada when HM eventually become available? Will HM be required to be approved by an European authority besides the one in The Netherlands and how long will this approval process take? In the event that HM would be released in The Netherlands before the U.S., would a person holding an American or Canadian passport be denied access to HM treatments? CANDIDATES How do you determine if a patient is a good candidate for HM ? Will there be a preliminary test to evaluate if a patient is responsive to the treatment ? Do you test HM on a small area on the patient to see if it works before you perform something more extensive ? Can HM benefit men and women with diffuse androgenetic alopecia? Will HM work on scar tissue from past hair transplant procedures ? How can you identify proper donor hair if someone just started losing his hair ? Would your treatment work for people who have suffered from hair loss due to Accutane treatment or Vitamin A overdose? Or, in general, would it work for people who have suffered from drug induced hairloss (if drug treatment has stopped)? Will the process of extracting hairs and determining their fitness for HM have an problem with follicles currently active by Propecia or Minoxidil ? In order words, does someone taking any kind of hair growth agent make identifying DHT resistant hair follicles more difficult ? Consider a man who is extensively bald with diffuse androgenetic alopecia so that he even has very little DHT resistant hair on his sides and back. Can you give him a full head of hair at a reasonable cost and in a reasonable time. The permanent hair at the sides and back are somewhat miniaturized in men who have extensive baldness. Are these miniaturized permanent hair suitable for culturing and if so, will the new hair inherit the characteristics of these miniaturized permanent hair and stay thin ? Would HM be effective on areas that have been damaged by regular use of minoxidil, commonly referred to as minoxidil burns ? The symptoms usually include severe scalp irritations, itch, excessive flakes or dandruff etc. Will hair texture, hair color, or ethnicity of the test subjects have any correlation with HM results? THE PROCEDURE How is HM administered? How long does a patient have to wait between HM sessions ? Will HM patients require booster or maintenance sessions to maintain the new hairs generated by HM? In their late teens or early twenties, most men undergo a transition unrelated to androgenetic alopecia from their teenage hairline to their adult hairline. In a balding patient, would you restore the teenage hairline? Would you restore the adult hair line? If not, how aggressive would you go about restoring the frontal hairline? Assuming that HM can now yield 60% density consistently from session to session on every patient and assuming that each HM session lasts 7 hours. How many HM sessions will be necessary to remedy someone's hair loss condition from Norwood 6 to Norwood 1? How long does it take before the new hair follicles start to grow from the time when we first visit your clinic ? COMPETITION Are you aware of the current "cell therapy" experiments being researched by physicians such as Dr. Walter Unger (University of Toronto)? What do you think of his research ? Is Dr. Unger doing essentially the same thing as you are ? Is there a fundamental difference between your "Hair Multiplication" and his "cell therapy" or are the differences just a matter of the variety of cells used ? COST Would HM be considerably less than traditional hair transplant? or a Norwood 7 to regain all his hair, would it cost him less than $10,000, $20,000, $30,000, etc? DENSITY / RESULTS What kind of density can we achieve ? Can we have a density like what we used to have when we were teenagers assuming we can afford numerous HM procedures ? Will HM create totally natural and undetectable hair? Can anyone tell that someone had HM done? Have you been able to grow cosmetically acceptable hair on your test subjects ? Were the results of your procedure cosmetically as good as a typical hair transplant in achieving an appearance of fullness of hair (overall appearance of density)? What is the success rate of HM ? In the event that some patients do not respond as well to HM as other patients do, can they still obtain the same final results by having more HM sessions performed? In order words, do some patients simply plateau at a lower density regardless of how many additional HM sessions are performed? Can poor initial results in density be compensated by multiple HM sessions ? What is the average density that can be achieved from one HM session? Will you be able to create a totally natural hairline using HM alone without hair transplantation? Based on your test results, can you tell us the average regrowth in terms of number of hairs per sq cm? HAIR TRANSPLANTATION If I am considering getting hair transplants from you today, would you recommend that I visit your clinic and inquire about Follicle Transplantation or should I just wait for your HM to become available ? Why are you offering a new hair transplantation procedure, ie: Follicle Transplantation, when HM is so close? TRIALS & TEST PATIENTS I understand that all patient info are confidential. But any chance that you can show me before and after pictures of HM's test subjects? I am willing to abide by any stipulation you may have with respect to information about the pictures. This question has been asked almost a thousand times by people in HairSite's forum. Would you consider letting 3 to 5 HairSite's visitors participate in your HM trials? Have you been able to grow a full head of hair for some test subjects? Do you have any statistics or tables of data that quantify your research so far and can you share some basic statistics with us? Is there any evidence from your findings that there is any correlation between length of time of hair loss or baldness and the success rate of HM? In order words, is there any statistical correlation, even a weak one, between these two variables? For example, HM worked well on 68% of test patients who have been bald or balding for less than 5 years. HM worked well on 53% of test patients who have been bald or balding for 5-10 years. HM worked well on 45% of test patients who have been bald or balding for 10-15 years. HM worked well on 37% of the test patients who have been bald or balding for 15-20 years. Basically we would like to know if the amount of time the patient has been bald a factor in his or her responsiveness to HM? In your clinical trials, have you actually covered the entire bald scalp of a patient or are you just testing on a certain area only? Can you tell us if you have actually cured someone of his baldness completely in your trials? When will you release results of your clinical trials? ISO CERTIFICATION Can you tell us the progress with ISO Certification ? Has ISO been filed at this point? TECHNICAL Will the new hair grow only where there was once used to be hair or will they grow wherever the cultured cells are injected regardless of whether there used to be hair or not on the scalp ? If the cultured hair cells exhibit the same properties, will the new hair go through the hair cycle (anagen, catagen, telogen) all at the same time ? What are the possibilities that the new hair will fall off simultaneously if they go through telogen all at the same time ? Are completely new follicles created or are old ones used with the addition of new HM cells ? The patent seems to suggest that new follicles are induced to grow, is this accurate ? If old follicles are induced to produce terminal hairs, what will prevent the cells in the matrix from still reacting to DHT or whatever is ultimately responsible for the follicle miniaturization from continuing to occur, making a treatment only a temporary solution ? If old follicles are being rejuvenated in the process, can we rejuvenate all old follicles regardless of how long they have remained inactive ? In HM, are you removing cells from follicles in non-DHT-affected areas, culturing those cells, and then transplanting or injecting the resulting cell lines INTO dormant follicles in balding areas of the scalp to stimulate the cells in those dormant follicles? In other words, does HM cause follicular neogenesis, ie: does it create brand new hair follicles which previously did not exist, and is this the PRIMARY mechanism by which HM grows hair ? Since you are injecting via the pores, is the functionality of the injected pore retained after it is injected, or is it in some way changed or damaged ? Do the cells injected with a single injection disperse when injected in the scalp and form follicles in somewhat different areas, or does each injection lead to only a single new follicle site, even if it turns out to be a multi-lobed follicle or two follicles jammed together etc? One of our posters has a very creative idea. I am going to quote what he said and perhaps you can give us your comments? "Why couldn't Dr. Gho simply remove the epidermis of the scalp with a laser as in cosmetic laser resurfacing and then bathe the treated area with the stem cell bath? In theory you should get decent diffusion through the treated surface tissue. have seen a number of patients that have had that sort of resurfacing and their skin looks brand new. As the tissue heals the stem cells could possibly get "trapped" below the newly forming epidermis and find their way to the dormant follicles. Or maybe even regrow as new follicles. It would hurt like hell post op but you could do wide areas at one sitting and it would be like casting seeds on newly fertile soil. Should get pretty fair and even distribution and the density would be less a function of operator skill and more a function of the patients innate ability to grow new follicles". What exactly is meant by the U.S protocol for HM? Does it refer to cell culture and tissue-handling standards promulgated by the U.S government (FDA)? We are not asking you to reveal proprietary information or trade secrets about your HM procedure. We are just asking why you use the term U.S protocol. Have you already contacted the FDA or other authority. LEGAL ISSUES Do you intend to vigorously enforce your patent ? Are you aware of the 1996 law passed in the U.S which prohibits patent infringement lawsuits against doctors who use medical procedures patented by others after the law became effective? MEDIA Certain HairSite contributors have developed contacts with reporters at two major American periodicals, the daily national newspaper USA Today, and the monthly scientific magazine Scientific American. They have become aware of your patent and the Gho-Clinic website. We also have a contact with a reporter at a major newspaper in Sweden. All three of these journalists would like very much to write major stories focusing on Hair Multiplication and the Gho-Clinic, to tell their readers about Dr. Gho's work. However, all three of these reporters will not write their stories unless they can have at least a brief interview with Dr. Gho, and ask him certain basic questions about HM and his plans for the near future. Would you consent to such interviews? If not now, when would you agree to be contacted by these journalists? If you will not consent to these interviews, please tell us why not. We will, of course, respect your wishes. OTHER How do Dutch people say your name? How does a doctor go about licensing HM procedure from you ? What are the possible complications associated with HM treatment? Any immediate plans for the future that you can share with us?

Figures Only for this Article Full Text of this Article Reprint (PDF) Version of this Article Email this article to a friend Related articles in JCS Similar articles found in: JCS Online PubMed PubMed Citation Search Medline for articles by: Lako, M. || Jahoda, C. A. B. Alert me when: new articles cite this article Download to Citation Manager Journal of Cell Science 115, 3967-3974 (2002) Copyright © 2002 The Company of Biologists Limited doi: 10.1242/jcs.00060 -------------------------------------------------------------------------------- Research Article Hair follicle dermal cells repopulate the mouse haematopoietic system Majlinda Lako, Lyle Armstrong, Paul M. Cairns, Sue Harris, Nicholas Hole* and Colin A. B. Jahoda* Department of Biological Sciences, South Road, University of Durham, Durham DH1 3LE, UK * Authors for correspondence (e-mail: [email protected]; [email protected]) Accepted 15 May 2002 Skin and hair follicle stem cell biology is the focus of increasing interest, not least because the adult hair follicle has well defined dermal and epithelial populations that display distinct developmental properties. Recent evidence suggests that a number of adult cell populations have much broader stem cell capabilities than previously thought. To examine whether this applied to the hair follicle, and with a view to developing the follicle as a stem cell model system we investigated whether adult hair follicles were capable of demonstrating haematopoietic stem cell activity. To investigate haematopoietic activity in hair follicles we first used in vitro haematopoietic colony assays. This demonstrated that rodent hair follicle end bulbs as well as micro-dissected dermal papilla and dermal sheath cells actively produced cells of erythroid and myeloid lineages but that follicle epithelial cells did not. As a more stringent test, we then transplanted cultured dermal papilla or dermal sheath cells from transgenically marked donor mice into lethally irradiated recipient mice and observed multi-lineage haematopoietic reconstitution when assayed at intervals of up to one year. Colony assays from bone marrow of primary recipients revealed that over 70% of clonogenic precursors were derived from donor hair follicle cells. When bone marrow from primary mice was harvested and used to repopulate secondary myeloablated recipients, multi-lineage haematopoietic engraftment was observed. Our data show that dermal but not epidermal compartments of the adult hair follicle have much broader stem cell activities than previously described. Although the treatment for many forms of blood disorder, such as leukemia, often requires transplantation of haematopoietic stem cells (HSC), their availability can be rate limiting. Given its easy accessibility, our identification of the hair follicle as a source of extramedullary haematopoietic stem cell activity makes it an attractive potential source for blood stem cell therapeutics and highlights its value as a model system in adult stem cell biology. Key words: Hair follicle, Dermal papilla, Dermal sheath, Haematopoietic stem cell Related articles in JCS: Turning hair follicles into blood JCS 2002 115: 2003. [Full Text]

read this and try to find if it's serious (thanks): http://www.sei.co.jp/top_e/f_press.html Che ne pensate?

Ciao Dario se la sicurmatica si trova nella tua città perchè non fai un salto subito invece di organizzare un incontro di massa..vista la tua esperienza ti basterà guardare una loro protesi per capire immediatamente se è valida?

Grazie Hal6969 farò questa ricerca..tu sei un chirurgo?

Nessuna novità?

Su novella 2000

Salve caro Dott. Tesauro!è possibile avere una sua opinione sulla tecnica del dott. Woods?Perchè non la impara a praticare anche lei?non è un po' triste quella cicatrice sulla nuca? Umilmente e cordialmente VIKINGO

Salve Sicurmatica posso fare una domanda? è possibile con la vostra protesi un taglio all'indietro con gel alla banderas? Forse con una base dell'attaccatura sottilissima..ma poi non è forse vero che una base fine e sottile praticamente inesistente come quella che utilizzano gli attori di cinema si deteriora subito?

omni che foltezza hai ? in controluce si vede il cuoio capelluto?

Ciao Sayan!Non voglio certo essere io a toglierti la speranza che la HM rinvigorisca i capelli esistenti ma come ha scritto Tristan le cellule vengono iniettate nel cuoio capelluto e non vedo come possano aiutare i capelli esistenti..E' come dire:"se mi faccio un trapianto rinvigorisco i capelli esistenti" sappiamo che non è cosi'.. comunque che ti frega se alla fine ti mettono migliaia di capelli nuovi???

Azz..

Nessuna provocazione ci mancherebbe!la HM non può essere utilizzata per far ricrescere o rinvigorire i capelli esistenti..ma dovrebbe garantire una illimitata quantità di capelli da impiantare

Quelli li perdi..

Il mio fruttivendolo sta facendo un corso privato dal dott Gho

Veramente molto interessante questo lavoro.Sarebbe importante anche il parere dei medici di salus,o sono troppo impegnati a fare i vecchi deprimenti trapianti?certo i compensi sono meno deprimenti..

Caro hall6969 ma lo parli l'inglese?non si parla di anni e anni! si parla di quattro al massimo!ho vissuto negli usa e sono costantemente in contatto con hairsite fidati!

Secondo me la questione è semplice: se la HM dovesse diventare realtà,cosa credi che farebbero dott. Tesauro and company? Perderebbero la possibilità di guadagnare molti soldi con i trapianti tradizionali: ecco perchè loro temono la HM e non ne parlano mai(se non mi ricordo male il dott Tesauro sosteneva "sperava" che la clonazione arrivasse tra 20 anni). xxxxx è triste dirlo ma per loro la nostra testa è un business che frutta molto bene.

Ciao ron2 caro collega anche tu in rete a quest'ora?che ne pensi dei ribassi della borsa ??na tragedia?dove hai studiato?

Ma esteticamente ti vedi cambiato ?se potessi tornare indietro lo rifaresti?