Interessante post di Bryan Shelton

[Dep]

Ho trovato questo post,grazie a una indicazione di HairGod , sul newsgroup alt.Baldspot:è sicuramente molto interessante!Quantifica la ricrescita di capelli dovuta all'utilizzo di finasteride,dutasteride(dati provenienti dalla fase II) e minoxidil.....

Non si vuole assolutamente sminuire le potenzialità degli inibitori del 5-alfa-reduttasi che sicuramente hanno un ruolo importantissimo nel bloccare o rallentare(sicuramente la dutasteride sarà piu' efficace da questo punto di vista) il processo di miniaturizzazione.....si vuole solo far vedere che la "pura" ricrescita risulta molto piu' accentuata utilizzando una soluzione topica di minoxidil 1%-2%-3%.

Come ben sappiamo poi,i risultati migliori si ottengono grazie alla combinazione di piu' prodotti che agiscono sotto varie angolazioni

 

Ecco l'originale:

 

"For quite some time now, I've been telling people that from my reading

of various topical minoxidil studies and finasteride studies, it appears

that minoxidil is more effective at stimulating regrowth than finasteride;

an obvious question nowadays would be: where does the very long-awaited

dutasteride fit into the grand scheme of things? We have some good data

from the dutasteride phase II trial, so does it finally surpass what Rogaine

can do? I decided to look at the data from every topical minoxidil study

in my collection and make an objective comparison! Since the only reported

data in the dutasteride trial were the hair-counts, I could only use minox

studies that also reported hair-counts, to get any kind of meaningful

comparison; and there are exactly six of them in my collection.

 

I've given the full citations to the studies at the very end of this post,

in case anyone wants to double-check my figures and computations. As I'm

reporting the numbers for each one, I'll just refer to them as (1) through

(6)...again, you can check at the end to see the full reference. The minox

studies lasted for varying lengths of time like 4 months, 6 months, and

12 months, while the Glaxo finasteride and dutasteride trial lasted only

for six months; to compensate for that, I've specified the actual length

of each individual trial, and then calculated the hair-count increase

PER MONTH, for fairness. Also, all hair-counts are standardized to the

familiar 1-inch circular test spot on the scalp. Ok...all set? Here we go:

 

(The Glaxo trial of finasteride and dutasteride)

 

Finasteride... +72 hairs, six months (12.0 hairs/month)

Dutasteride... +108 hairs, six months (18.0 hairs/month)

 

 

(All the following are the topical minox studies)

 

(1) 2% minox... +425 hairs, 12 months (35.4 hairs/month)

Also: 3% minox... +372 hairs, 12 months (31.0 hairs/month)

 

(2) 2% minox... +273.4 NONVELLUS hairs, 12 months (22.8 hairs/month)

 

(3) 2% minox... +101 TERMINAL hairs, 13 months (7.8 terminal hairs/month)

 

(4) 1% minox... +149 hairs, 6 months (24.8 hairs/month)

Also: 2% minox... +175 hairs, 6 months (29.2 hairs/month)

 

(5) 2% minox... +233.8 hairs, 12 months (19.5 hairs/month)

 

(6) 2% minox... +151 hairs, 4 months (37.8 hairs/month)

Also: 2% minox... +324 hairs, 12 months (27 hairs/month)

Also: 3% minox... +166 hairs, 4 months (41.5 hairs/month)

Also: 3% minox... +338 hairs, 12 months (28.2 hairs/month)

 

 

There you have all the data! Averaging all the topical minoxidil data

shows an average hair-count increase of +25.1 hairs per month (for that

study #6, I'm using just the 12-month data), whereas dutasteride only

managed a hair-count increase of +18.0 hairs per month! Finasteride

brings up the rear at only +12.0 hairs per month! Summarizing the data

is very simple and elegant: dutasteride generates about 50% more

regrowth than finasteride (we've been saying that for a long time),

and topical minoxidil generates about 50% more regrowth than

dutasteride, according to all these studies! And here's a small

but important detail: the minoxidil hair-counts are actually a little

UNDERestimated, because the numbers reported for studies #2 and #3

were for nonvellus and terminal hairs, respectively. Factoring in

TOTAL hair-counts (which weren't reported in those two studies)

would make regrowth from topical minoxidil even more impressive.

 

Bottom line: as I've been saying for a long time, dutasteride is a fine

new addition to our weaponry, but it should be considered a potent agent

to inhibit the balding process itself, and not really something that's

going to stimulate a lot of extra regrowth. For that, you'll have to use

a complete program that addresses all the known angles that we've been

talking about, like minoxidil, SODs, etc. By no means is dutasteride

all by itself any kind of ultimate "cure" for balding; at least, not if

any serious regrowth is one of your goals. But if all you need to do is

maintain, then it should be an outstanding new drug for you, even by itself.

 

Bryan

 

 

(1) "Topical Minoxidil in Early Androgenetic Alopecia", Kreindler et al,

J Am Acad Dermatol 1987;16:718-24.

 

(2) "Five-Year Follow-Up of Men With Androgenetic Alopecia Treated With

Topical Minoxidil", Olsen et al, J Am Acad Dermatol 1990;22:643-6.

 

(3) "Duration of Minoxidil Therapy to Yield Maximum Benefit", [Letter]

Rietschel et al, Arch Dermatol 1988;124:1569-70.

 

(4) "Dose-Response Study of Topical Minoxidil in Male Pattern Baldness",

Olsen et al, J Am Acad Dermatol 15:30-37, 1986.

 

(5) "Topical Minoxidil Therapy for Androgenetic Alopecia", Koperski et al,

Arch Dermatol 1987;123:1483-1487.

 

(6) "Topical Minoxidil in Early Male Pattern Baldness", Olsen et al,

J Am Acad Dermatol 13:185-192, 1985."

 

 

-Dep-